A trial looking at patupilone (Epo906) for people with advanced bowel cancer (CINATRA)

Cancer type:

Bowel (colorectal) cancer
Colon cancer
Rectal cancer




Phase 2

This trial looked at a new chemotherapy drug called patupilone for people with bowel cancer (colorectal cancer) that had spread locally, or to other parts of the body (metastatic).

Advanced bowel cancer is usually treated with chemotherapy. Capecitabine, oxaliplatin and irinotecan are some of the standard chemotherapy drugs doctors use. These drugs may help to control the growth of the cancer and to relieve symptoms. But if the cancer continues to grow or comes back, it becomes more difficult to treat.

An earlier phase 1 trial looked at patupilone (also called Epo906) in people who had already had standard chemotherapy for bowel cancer. Some people’s cancer shrank or stayed the same. So the results were promising but they need to be confirmed with a larger number of patients.

Bowel cancers have different types of changes in the DNA. Most have changes called chromosomal instability. A small number have DNA changes called microsatellite instability. Patupilone works by stopping the cancer cells from dividing and multiplying. And doctors think that it may work differently, depending on the type of changes in the cancer’s DNA.

This trial aimed to find out if patupilone

  • Could shrink or control the growth of bowel cancer
  • Worked better for bowel cancer when the DNA had microsatellite instability rather than chromosomal instability

Summary of results

The trial team found that patupilone didn’t shrink or control the growth of bowel cancer.

This was a phase 2 trial. Everyone had patupilone.

It was intended to recruit 110 people. But after recruiting 29 people, the team suggested closing the trial early. This was due to the side effects people had, especially diarrhoea. The committee that looks at the safety of the trial (Data Management Committee) agreed to close the trial early.

The most significant common side effects were

At 3 months the team found that no one’s cancer had responded to treatment. The average overall time that people survived was just over 6 months.

Because the trial closed early the trial team were unable to find out if patupilone worked better for bowel cancer that had DNA microsatellite instability rather than chromosomal instability.

The trial team concluded that patupilone had serious side effects and there was no evidence it helped people who have had previous treatment for bowel cancer.  

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewed Open a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr I. Chau

Supported by

NIHR Royal Marsden Biomedical Research Centre
Novartis Pharmaceuticals UK
The Royal Marsden NHS Foundation Trust

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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