A trial looking at new treatments for follicular lymphoma (REFRACT)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have follicular lymphoma that has come back (relapsed) or continued to grow despite treatment (refractory) and your doctor thinks systemic treatment could help 
• have follicular lymphoma that is low grade or slow growing and this was confirmed when you had a tissue sample (biopsy ) taken in the last 6 months. Your doctor will know this. 
• have the protein CD20 on the surface of lymphoma cells (CD20 positive). Your doctor will know this. 
• are suitable to have standard treatment
• have had at least one course of treatment in the past that included a combination of immunotherapy and chemotherapy. You can take part if you have already had radiotherapy or rituximab on its own. 
• have lymphoma that the doctor can assess on a scan
• are up and about for at least half the day but might not be able to work (performance status 0,1 or 2) 
• have satisfactory blood test results 
• are willing to use reliable contraception during the trial and for a period after if there is any chance you or your partner could become pregnant 
• give informed consent
• are at least 18 years old 

Who can’t take part

Cancer related 
You cannot join this trial if any of these apply. You:

• have high grade or faster growing lymphoma or you had this in the past. Your doctor will know this. 
• have lymphoma in the brain or spinal cord or you have had this in the past 
• have had a stem cell transplant with someone else’s cells 
• have had lenalidomide within 12 months of starting trial treatment 
• have had epcoritamab or a similar drug in the past 
• have had CAR T-cell treatment within 100 days of starting trial treatment 
• are going to have a stem cell transplant or maintenance treatment within 6 months of starting trial treatment 
• have had immunotherapy in combination with chemotherapy that included a platinum drug
• have had cancer treatment in the last 4 weeks such as immunotherapy, chemotherapy or a targeted cancer drug. Or you have had steroid treatment in the last 7 days unless it was a low dose. 
• have had another cancer within 2 years of joining the trial. You can take part if you had early cancer of the cervix, non melanoma skin cancer , early bladder cancer or prostate cancer or another cancer that has been successfully treated and there have been no signs of it for 2 years.

Medical conditions
You cannot join this trial if any of these apply. You:

• have had a heart attack in the last 6 months or you have a significant heart problem that needs treatment 
• have had major surgery within 30 days of starting trial treatment 
• have HIV, hepatitis C that isn’t well controlled with medication, an active hepatitis B infection or another active infection that needs treatment 
• are having or have had recent steroid treatment to damp down the immune system unless it is a low dose
• have had an organ transplant
• have another medical condition or mental health condition that could affect you taking part 

Other 
You cannot join this trial if any of these apply. You:

• are allergic to rituximab or similar drugs
• are allergic to any of the drugs in the trial. You might be able to join if you are allergic to a particular standard treatment and not allergic to other potential standard treatment. 
• are pregnant or breastfeeding