
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
This trial compared people having blood donated from a volunteer with people having their own blood returned to them. It was for women having an operation for advanced ovarian cancer.
Collecting someone’s blood and giving it back to them during surgery is called intraoperative cell salvage, or ICS.
The trial was open for people to join between 2016 and 2018. The team presented some results at a conference in 2019.
Doctors often treat ovarian cancer with surgery. Sometimes people need a blood transfusion during their operation. When this trial was done, doctors usually used blood that had been donated by a healthy volunteer. This is organised by the NHS Blood and Transplant service.
Blood transfusions from a donor are generally very safe and have been used for many decades. But there are some rare side effects that can happen, including:
There is also a very small risk of receiving the wrong blood type. But this is very rare.
Researchers wanted to find out if it is better to give people back their own blood. They can collect, filter and return a person’s blood during surgery. This is called intraoperative cell salvage (ICS).
When this trial was done, doctors were already using ICS during some operations. There was some evidence that it might help people to recover after surgery.
The main aims of this trial were to find out:
The research team found that it was safe to give people their own blood during surgery for ovarian cancer.
Results
A total of 57 people joined this trial. Two people weren’t well enough to have surgery so 55 were put into a treatment group at random. There were:
Of those, 30 needed a blood transfusion during their operation:
• 14 out of 29 people (48%) had blood donated by a healthy volunteer
• 16 out of 26 people (62%) had their own blood returned to them
Side effects
The research team looked at the number of people in each group who had an infection after their operation. The most common were wound, urine and lung infections.
They found it was:
• 13 out of 29 people (45%) in the donated blood group
• 9 out of 26 people (35%) in the ICS group
Conclusion
The research team concluded that it was safe to collect and return blood to people during surgery for ovarian cancer. And that this could be a good alternative to using blood donated by a healthy volunteer.
They suggest this is looked at in larger trials to find out more about how well it works.
Where this information comes from
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists but may not have been published in a medical journal. The figures we quote above were provided by the research team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Miss Khadra Galaal
NIHR Research for Patient Benefit (RfPB) Programme
Peninsula Clinical Trials Unit at Plymouth University
Royal Cornwall Hospitals NHS Trust
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.