A trial comparing different ways of checking lymph nodes in the chest for non small cell lung cancer (ASTER)
Cancer type:
Status:
Phase:
The aim of this trial was to see if internal ultrasound scans were as good as surgery for checking lymph nodes in the chest for lung cancer.
Doctors use a number of different tests to find out the stage of lung cancer. This helps them to decide on the best treatment.
One of these tests is a 
in the middle of your chest (). You usually have this done under general . But doctors thought that internal ultrasound scans may be useful. You have this done with a and a local anaesthetic.
To have this test a small ultrasound probe is put into your food pipe and stomach (an , or EUS). And another is put into your wind pipe and lungs (an , or EBUS). Using ultrasound, doctors can see the lymph nodes in your chest. If they see any abnormal areas, they will take a sample of tissue (a biopsy).
Some hospitals already use ultrasound scans to look at lymph nodes. But doctors were not sure if they were as good as having surgery.
The aim of this trial was to find out if using ultrasound scans is as good as taking surgical biopsies to assess lymph nodes.
Summary of results
The trial team found that using ultrasound scans worked just as well as taking biopsies to assess lymph nodes.
This phase 3 trial recruited 241 people. It was a randomised trial. Those taking part were put into 1 of 2 groups
- 118 had surgical biopsies taken of the lymph nodes
- 123 had endoscopic ultrasound (EUS) and endobronchial ultrasound (EBUS) followed by a surgical biopsy if the ultrasounds did not find any of the lymph nodes to be abnormal
The researchers then compared how accurate the 2 different ways of assessing the lymph nodes were. They found it worked
- 79 out of every 100 times (79%) for surgical biopsies
- 94 out of every 100 times (94%) for EUS and EBUS
They found no difference in the number of complications between surgery and ultrasound.
The trial team concluded that EUS and EBUS worked just as well as taking surgical biopsies to assess lymph nodes.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists () and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Chief Investigator
Dr Robert Rintoul
Supported by
Health Technology Assessment Unit of the Department of Health
National Institute for Health Research Cancer Research Network (NCRN)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
