
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
This is a study to find out more about how kidney cancer develops and how it spreads.
It is for people in one of the following situations you:
The main treatment for early kidney cancer is surgery. For some people their kidney cancer can come back after surgery. Why this happens isn’t understood.
Doctors can use drug treatment to shrink or slow the growth of kidney cancer that has come back or spread to another part of the body. But over time they can stop working. And the drugs can have unwanted side effects.
Researchers want to learn more about kidney cancer and why these things happen. In this study they will ask for people to give:
They will look at the genes () of the cancer cells in these samples to find out why:
Please note, you will not benefit directly from taking part in this study. But the results may help to improve our knowledge of cancer and improve cancer treatments in the future.
The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this study if one of the following apply. You:
or
or
And both of the following apply. You are:
Who can’t take part
You cannot join this study if any of these apply.
The study team need 672 people to take part.
You give extra blood samples and urine samples as part of this study. Where possible these are taken when you have routine blood and urine samples done.
You also give permission for the trial team to access samples of tissue (biopsy) you have taken. This includes tissue taken out if you have surgery in the future or had surgery in the past.
We have information about what to expect when having a kidney biopsy
Optional extra tissue samples
Depending on where you are with your treatment the team may ask you to give some extra cancer tissue samples. Where possible they will take the samples when you are having tissue samples taken as part of your routine care. This could be:
You don’t have to agree to give these extra tissue samples.
Researchers now and in the future will use these samples to look at the DNA of kidney cancer cells. They hope to learn more about kidney cancer and to gain better understanding as to why some treatments do or do not work.
CAPTURE Sub study
In this sub study the team looked at how well COVID-19 vaccines worked for people with cancer. We have the results of the CAPTURE sub study.
There are no extra hospital visits if you take part.
After having a sample of tissue (biopsy) taken you might have:
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Samra Turajlic
The Royal Marsden NHS Foundation Trust
National Institute for Health Research (NIHR)
Freephone 0808 800 4040
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.