"I am glad that taking part in a trial might help others on their own cancer journey.”
A study to find more about acute lymphoblastic leukaemia (UKALL14 sub study)
This study is open to people who are newly diagnosed with B cell acute lymphoblastic leukaemia (ALL) and haven’t started treatment. It is a sub study of the original UKALL14 trial.
In particular, it is for
- adults between 25 and 65 years old with B cell acute lymphoblastic leukaemia
- and for people between 19 and 65 who have ALL with the
Cancer Research UK supports this study.
More about this trial
The UKALL14 trial is looking at different treatments for ALL.
The team would now like to do a sub study to find out more about the genes of the leukaemic cells. They also want to find out more about whether they can predict how well treatment will work based on these changes.
In this study you have the standard chemotherapy treatment for ALL at your hospital. The study team will ask for small amount of your
They are looking for a substance (
Who can enter
The following bullet points list the entry conditions for this study. Talk to your doctor or the study if you are unsure about any of these. They will be able to advise you.
You may be able to join this study if all of the following apply. You:
- have recently been diagnosed with acute lymphoblastic leukaemia (ALL) and have not yet had any treatment apart from steroids
- are between 25 and 65 years old (inclusive)
you are between 19 and 65 and you have ALL with the
You cannot join this study if any of these apply. You:
- have a mature B cell leukaemia such as
Burkitt type ALL
- are in the blast transformation stage
- have chronic myeloid leukaemia (CML)
- are known to be HIV positive
- are known to have hepatitis B or hepatitis C
- are pregnant or breastfeeding
The study team need about 250 people to join this study.
Before starting treatment you have a bone marrow sample. This is a routine sample. The study team will ask for a small amount of this sample.
The team will ask for a blood sample if there isn’t enough of the bone marrow sample for them.
You then have treatment as normal. The main treatment for ALL is chemotherapy. Your doctor will decide the best treatment for you. This is likely to be based on the
There are different phases of ALL treatment:
You might have a
There are no extra hospitals visits.
How to join a clinical trial
Professor Adele Fielding
Cancer Research UK
NIHR Clinical Research Network: Cancer
CRUK & UCL Cancer Trials Centre
Chugai Pharma UK Ltd