A study to find more about acute lymphoblastic leukaemia (UKALL14 sub study)

Cancer type:

Acute leukaemia
Acute lymphoblastic leukaemia (ALL)
Blood cancers
Leukaemia

Status:

Open

Phase:

Other

This study is open to people who are newly diagnosed with B cell acute lymphoblastic leukaemia (ALL) and haven’t started treatment. It is a sub study of the original UKALL14 trial. 

In particular, it is for

  • adults between 25 and 65 years old with B cell acute lymphoblastic leukaemia
  • and for people between 19 and 65 who have ALL with the Philadelphia chromosome Open a glossary item.

Cancer Research UK supports this study.

More about this trial

The UKALL14 trial is looking at different treatments for ALL. 

The team would now like to do a sub study to find out more about the genes of the leukaemic cells. They also want to find out more about whether they can predict how well treatment will work based on these changes.

In this study you have the standard chemotherapy treatment for ALL at your hospital. The study team will ask for small amount of your bone marrow sample Open a glossary item that is taken before starting your treatment.

They are looking for a substance (biomarker Open a glossary item) in the sample they can use to follow how well your leukaemia responds to treatment. They are also looking for any gene changes in the cells of your leukaemia.

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study if you are unsure about any of these. They will be able to advise you.

You may be able to join this study if all of the following apply. You:

  • have recently been diagnosed with acute lymphoblastic leukaemia (ALL) and have not yet had any treatment apart from steroids
  • are between 25 and 65 years old (inclusive)
    or
    you are between 19 and 65 and you have ALL with the Philadelphia chromosome Open a glossary item

You cannot join this study if any of these apply. You:

  • have a mature B cell leukaemia such as Burkitt type ALL Open a glossary item
  • are in the blast transformation stage
  • have chronic myeloid leukaemia (CML)
  • are known to be HIV positive
  • are known to have hepatitis B or hepatitis C
  • are pregnant or breastfeeding

Trial design

The study team need about 250 people to join this study.

Samples
Before starting treatment you have a bone marrow sample. This is a routine sample. The study team will ask for a small amount of this sample.

The team will ask for a blood sample if there isn’t enough of the bone marrow sample for them.

You then have treatment as normal. The main treatment for ALL is chemotherapy. Your doctor will decide the best treatment for you. This is likely to be based on the standard treatment Open a glossary item given at your local hospital. 

There are different phases of ALL treatment:

  • induction
  • consolidation
  • maintenance

You might have a stem cell transplant Open a glossary item or bone marrow transplant Open a glossary item if you have a suitable donor and your ALL is at a high risk of coming back after chemotherapy.

Hospital visits

There are no extra hospitals visits.

Side effects

Your doctor will talk to you about the side effects of your chemotherapy treatment.

We have information about of the side effects of chemotherapy for ALL.

We have information about stem cell transplants and bone marrow transplants.

Location

Aberdeen
Airdrie
Bangor
Basingstoke
Bath
Belfast
Birmingham
Blackpool
Bournemouth
Bradford
Cambridge
Cardiff
Cheltenham
Chichester
Cottingham
Coventry
Dewsbury
Dudley
Dundee
Dunfermline
East Kilbride
Edinburgh
Exeter
Glasgow
Gloucester
Hampshire
Ipswich
Kirkcaldy
Leeds
Leicester
Liverpool
London
Manchester
Middlesbrough
Newcastle upon Tyne
Northallerton
Nottingham
Oxford
Perth
Plymouth
Pontefract
Poole
Portsmouth
Rhyl
Sheffield
Stoke-on-Trent
Sutton
Swansea
Taunton
Torbay
Truro
Wakefield
West Bromwich
Wirral
Wishaw
Worthing

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Adele Fielding

Supported by

Cancer Research UK
NIHR Clinical Research Network: Cancer
Novartis
Roche
CRUK & UCL Cancer Trials Centre
Chugai Pharma UK Ltd
Biovitrum
Sigma Tau
Baxalta

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

15400

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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