"He went through six operations and was placed on a clinical trial so he could try new treatments.”
A study to develop and test a computer programme to help better identify when brain tumours continue to grow after treatment
Cancer type:
Brain (and spinal cord) tumours
Status:
Open
Phase:
Other
This study is looking at developing and testing a computer programme to show the difference to the brain tumour getting worse and side effects of treatment.
It is open to people with a type of brain tumour called glioblastoma.
More about this trial
Doctors use chemotherapy at the same time as radiotherapy to treat glioblastoma. Chemotherapy and radiotherapy together is called chemoradiotherapy. After treatment it might feel like your symptoms are getting worse. This is because radiotherapy can cause the brain to swell. But in some cases it might be because the tumour is continuing to grow.
You have 
before starting treatment and after finishing treatment. Doctors look at the scans to see if treatment worked. But it can be difficult to tell the difference between swelling of the brain and whether the tumour is getting worse.
In this study researchers want to test a computer programme that they have developed. They hope that the computer programme will be able to tell the difference between the tumour growing and swelling of the brain. To do this they will look at your medical notes and use MRI scans after your treatment.
The aims of this study are to test the computer programme and prove its usefulness.
Who can enter
The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this study if all of the following apply. You:
- have glioblastoma that is fast growing (stage 4)
- have had treatment with radiotherapy along with temozolomide (chemoradiotherapy) followed by chemotherapy with temozolomide
- have had a scan before treatment and at least 1 scan after treatment
- are 18 to 80 years old
Who can’t take part
You cannot join this study if any of these apply. You:
- have not had enough scans after treatment
- have had treatment that greatly differs from chemoradiotherapy followed by chemotherapy
- have had treatment that stops the growth of new blood vessels such as bevacizumab before finishing chemoradiotherapy followed by chemotherapy
Trial design
The team need 350 people to join the study.
Researchers will look at your medical notes, scans and scan results. They will use this information to test the computer programme.
Hospital visits
There are no extra hospital visits if you join the study
Side effects
There are no side effects to taking part in this study.
Location
Cardiff
Dundee
East Sussex
Hull
Leeds
London
Manchester
Newcastle upon Tyne
Nottingham
Plymouth
Preston
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Dr Thomas C Booth
Supported by
Guy's and St Thomas' NHS Foundation Trust
King's College London
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Last review date
CRUK internal database number:
17282
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Rhys was only four years old when he was diagnosed with a brain tumour
