A study to develop and test a computer programme to help better identify when brain tumours continue to grow after treatment

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Brain (and spinal cord) tumours





This study is looking at developing and testing a computer programme to show the difference to the brain tumour getting worse and side effects of treatment.

It is open to people with a type of brain tumour called glioblastoma.

More about this trial

Doctors use chemotherapy at the same time as radiotherapy to treat glioblastoma. Chemotherapy and radiotherapy together is called chemoradiotherapy. After treatment it might feel like your symptoms are getting worse. This is because radiotherapy can cause the brain to swell. But in some cases it might be because the tumour is continuing to grow. 

You have MRI scans Open a glossary item before starting treatment and after finishing treatment. Doctors look at the scans to see if treatment worked. But it can be difficult to tell the difference between swelling of the brain and whether the tumour is getting worse. 

In this study researchers want to test a computer programme that they have developed. They hope that the computer programme will be able to tell the difference between the tumour growing and swelling of the brain. To do this they will look at your medical notes and use MRI scans after your treatment. 

The aims of this study are to test the computer programme and prove its usefulness.

Who can enter

The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply. You:

  • have glioblastoma that is fast growing (stage 4)
  • have had treatment with radiotherapy along with temozolomide (chemoradiotherapy) followed by chemotherapy with temozolomide
  • have had a scan before treatment and at least 1 scan after treatment
  • are 18 to 80 years old

Who can’t take part

You cannot join this study if any of these apply. You:

  • have not had enough scans after treatment
  • have had treatment that greatly differs from chemoradiotherapy followed by chemotherapy
  • have had treatment that stops the growth of new blood vessels such as bevacizumab before finishing chemoradiotherapy followed by chemotherapy

Trial design

The team need 350 people to join the study. 

Researchers will look at your medical notes, scans and scan results. They will use this information to test the computer programme.

Hospital visits

There are no extra hospital visits if you join the study

Side effects

There are no side effects to taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Thomas C Booth

Supported by

Guy's and St Thomas' NHS Foundation Trust
King's College London

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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