Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
A study of genetic causes of kidney cancer
Cancer type:
Kidney cancer
Renal cell cancer
Status:
Open
Phase:
Other
This study is looking at blood samples to find out more about the genetic causes of kidney cancer.
There are many risk factors associated with developing renal cell carcinoma (RCC). This is the most common form of kidney cancer. There are some faulty genes and inherited conditions that increase risk.
This study is looking at people who may have an inherited genetic fault or medical condition that increases their risk of developing RCC. The aim of the study is to find out more about the genetic causes of RCC, and more about how gene faults may increase risk.
Who can enter
You can enter this trial if you have one of the following. You:
- have 2 close relatives diagnosed with RCC before the age of 60 (or one close relative if you have been diagnosed with RCC before the age of 60)
- have 3 close relatives diagnosed with RCC at any age (or 2 close relatives if you have been diagnosed with RCC)
- were diagnosed with RCC before the age of 35 (early onset RCC)
- have had RCC in both kidneys (bilateral RCC) before age 50
- have Birt-Hogg-Dube syndrome
Please note, a close relative can be either:
- a first degree relative - parent, child, brother or sister
- a second degree relative - aunt, uncle, grandparent, grandchild, niece, nephew, half brother or half sister
Trial design
You will fill out a family history questionnaire. This will ask you about your parents, brothers, sisters and children, and whether any of them have had cancer.
The doctors will take a blood sample. They will use this sample to look for genes that are known to increase risk of kidney cancer. They will also look for possible new genes that may increase risk. This is for research only, and won’t be used for diagnosis. The results won’t affect the care or treatment you or your relatives have.
Hospital visits
This trial is being coordinated in Cambridge, but people can take part across the country. You go to the hospital or to your GP surgery to have a blood sample taken. Apart from that, you won’t have any extra trips to hospital as a result of taking part in this trial. The research team will send you the questionnaire to fill out and post back to them.
Side effects
You may get a small bruise when you have the blood sample taken. There are no other side effects associated with this trial.
Location
Aberdeen
Belfast
Birmingham
Bristol
Cambridge
Cardiff
Dundee
Edinburgh
Exeter
Glasgow
Leeds
Leicester
Liverpool
London
Manchester
Newcastle upon Tyne
Nottingham
Oxford
Sheffield
Southampton
Sutton
Recruitment start:
Recruitment end:
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Chief Investigator
Professor Eamonn Maher
Supported by
Cancer Research UK
European Research Council (ERC)
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Last review date
CRUK internal database number:
447
Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.
Over 60,000 cancer patients enrolled on clinical trials in the UK last year.
