A study looking at high resolution ultrasound to diagnose prostate cancer

Cancer type:

Prostate cancer

Status:

Open

Phase:

Other

This study is looking at using 2 different contrast mediums Open a glossary item used in ultrasounds Open a glossary item that might give a better picture of the prostate. 

It is open to people who are due to have surgery to remove their prostate.

More about this trial

To diagnose prostate cancer doctors usually take samples of the prostate tissue (biopsies Open a glossary item). They usually do this with a trans rectal ultrasound (TRUS). They call this a trans rectal ultrasound guided biopsy

In this study the team will use super-resolution ultrasound imaging (SRI). Doctors already use SRI in other diseases but not prostate cancer. They think SRI might give a clearer view of the prostate. And so might be able to detect cancer in the prostate earlier. 

To find this out they first need to see how well SRI works when using it to look at the prostate. 

In this study you have your surgery as normal. The team use SRI before the surgeon begins the operation. 

The 2 different contrast mediums the team is using are:

  • Sonovue
  • Luminity

You have only 1 of these contrast mediums. 

The aims of this study are to see:

  • whether SRI is better at detecting prostate cancer
  • which contrast medium is best  

Please note you will not benefit directly if you take part in the study. The results of this study might help people in the future who have prostate cancer.

Who can enter

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply. You:

  • have or might have prostate cancer   
  • are due to have surgery to remove your prostate (radical prostatectomy) as your main treatment
  • are able to have a trans rectal ultrasound. Your doctor will know if you can.  

Who can’t take part

You cannot join this study if any of these apply. You:

  • have a heart problem Open a glossary item. Your doctor checks this before you take part in the study. 
  • are allergic or sensitive to the contrast mediums used for the ultrasound in this study 

Trial design

The team need 25 people to take part. 

You have your prostate surgery as normal. 

You have a general anaesthetic Open a glossary item. You then have either an injection or a drip containing 1 of the contrast mediums (Sonovue or Luminity). Before your  operation you have an ultrasound probe put in your back passage. 

The contrast medium shows up the prostate on the screen of the ultrasound. The radiologist Open a glossary item takes pictures of the prostate. This takes between 20 and 40 minutes. 

Samples for research
The team might take and store any normal tissue and prostate cancer tissue that is left over from surgery that might be discarded. Researchers might use this tissue in future research to find out more about prostate cancer.

Hospital visits

There are no extra hospital visits if you take part in the study.

Side effects

The 2 contrast mediums are routinely used for ultrasounds in other health conditions and are safe. 

The side effects of the contrast mediums include:

  • headaches
  • flushing
  • itching and redness at the injection site
  • skin rash
  • muscle and joint pain
  • heartburn
  • cough
  • dry throat
  • high or low blood pressure
  • fainting
  • changes to the heartbeat

We have information about having surgery to remove the prostate.

Location

Edinburgh

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Alan McNeill

Supported by

Heriot Watt University
NHS Lothian
The Chief Scientist Office of Scotland

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

16341

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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