
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at what happens to chemotherapy drugs in the body during treatment for Ewing’s sarcoma. The study is supported by Cancer Research UK.
This study is for both adults and children. We use the term ‘you’ in this summary, but of course if you are a parent, we are referring to your child.
Treatment for Ewing’s sarcoma usually includes chemotherapy. You may have treatment that includes the drugs:
Doctors call this VDC/IE.
We know from research that there are variations in how people get rid of these drugs from their bodies. In this study, researchers are measuring levels of the drugs in the blood after treatment. It is called a pharmacokinetic study.
The main aims of the study are to see
Taking part in this study will not affect the treatment you have. The results may improve the way doctors use these chemotherapy drugs in the future.
You may be able to enter this study if you
You cannot enter the study if
The study will recruit 140 people having chemotherapy for Ewing’s sarcoma.
You have chemotherapy in cycles of treatment. If you take part in this study, the study team will take a number of blood samples during 2 cycles of your chemotherapy treatment.
They will take the blood from your central line so you won’t need to have any extra needles.
The study team will also take extra samples to study certain genes that may control how fast the drugs are removed from your body and to see if they can predict which patients may be more likely to have side effects. They will take this sample before you start your 1st cycle of chemotherapy. The researchers want to see if they can work out at an early stage in treatment who is likely to get infections or a sore mouth because of the chemotherapy.
Taking part in the study doesn’t involve any extra hospital visits.
There are no side effects from taking part in this study.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Quentin Campbell Hewson
Cancer Research UK
The Newcastle upon Tyne Hospitals NHS Foundation Trust
University of Newcastle
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.