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A trial looking at selumetinib and dexamethasone for acute lymphoblastic leukaemia (SeluDex)

Overview

Cancer types:

Acute leukaemia, Acute lymphoblastic leukaemia (ALL), Blood cancers, Children's cancers, Leukaemia

Status:

Closed

Phase:

Phase 1/2

Details

This trial is looking at combining selumetinib with dexamethasone for children and adults with acute lymphoblastic leukaemia (ALL).

It is open to people with ALL that has come back after treatment (relapsed) or has continued to get worse during treatment (refractory). And the leukaemia has a gene change (mutation) in the RAS-pathway that controls the MEK protein.

Cancer Research UK supports this trial.

Recruitment start: 17 April 2018

Recruitment end: 31 December 2022

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Tobias Menne

Supported by

AstraZeneca

Cancer Research UK

University of Birmingham

Last reviewed: 4 August 2024

CRUK internal database number: 14315

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