A trial of chemotherapy and immunotherapy for non small cell lung cancer (Skyscraper 06)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have non small cell cancer that has spread into surrounding tissues and you can’t have surgery to remove it or the cancer has spread to another part of the body 
• haven’t had treatment that reaches the whole body (systemic treatment) , for example chemotherapy or immunotherapy. You may be able to take part if you had certain treatments before surgery with the aim to cure your cancer. Your doctor checks when you had this to see if you can take part. 
• have a tumour sample available for the trial team to do some tests on or you are willing to give a new sample if this is possible
• may or may not have certain proteins (receptors) called PD-L1 on the surface of the cancer cells. Your doctor needs to know this and will check. 
• have cancer that the doctor can see and measure on a scan 
• are on a stable dose of medication to thin the blood if you take this
• have satisfactory blood test results
• are well enough to carry out all your normal activities, but might not be able to do heavy physical work (performance status of 0 or 1)
• are willing to use reliable contraception during treatment and for a period of time after if there is any chance you or your partner could become pregnant
• are at least 18 years old 

Who can’t take part

You cannot join this trial if any of these apply. 

Cancer related 
You:

• have a type of non small cell lung cancer called pulmonary lymphoepithelioma-like carcinoma. Your doctor will know this. 
• have cancer that has both non small cell lung cancer cells and small cell cancer cells
• have a change (mutation ) in the EGFR or ALK genes on the lung cancer cells 
• have cancer that has spread to the brain or spinal cord that is causing symptoms, getting worse or hasn’t been treated 
• have cancer that has spread to the thin layers of tissue that cover the brain and spinal cord (leptomeningeal metastases)
• have had treatment within 3 weeks for your cancer including hormone treatment  before starting trial treatment 
• have had tiragolumab, atezolizumab or similar drugs in the past
• have a condition called spinal cord compression  that hasn’t been treated or isn’t stable
• have pain from your cancer that isn’t controlled with medication 
• have had another cancer that has got worse or needed treatment in the past 5 years. This is apart from successfully treated non melanoma skin cancer , carcinoma in situ (CIS)   of the cervix, early prostate cancer, DCIS  of the breast or early womb cancer
• have had an experimental drug in the last month     

Medical conditions
You cannot join this trial if any of these apply. You:

• have areas of fluid on the lung, heart or tummy that need frequent draining 
• have high levels of calcium  in the blood and treatment for this isn’t working 
• have or have had an autoimmune disease  or a problem with your immune system . This is apart from certain ones. Your doctor checks this.
• have scarring of the lungs (pneumonitis ) that shows up on a scan unless you had radiotherapy to that area
• have a severe liver problem and it doesn't work well. Your doctor checks this. 
• have had a heart attack or stroke in the last 3 months or a significant heart problem  that needs treatment. The trial team check if you have a heart condition before you join the trial. 
• have had major surgery in the last month. This is apart from surgery to diagnose your cancer. 
• have had a stem cell transplant  with someone else’s cells or an organ transplant   in the past 
• have had treatment to stimulate the immune system . This includes interferon in the last 2 weeks or if treatment hasn’t completely cleared your body.
• have had treatment that damps down the immune system or you might need to start this treatment. This includes steroids  within 2 weeks of starting trial treatment unless it was a low dose. 
• have a problem with your hearing if you are due to have cisplatin 
• have moderate numbness and tingling in your hands or feet from past side effects if you are having cisplatin 
• have HIV, an active hepatitis B or hepatitis C infection, active tuberculosis (TB), Epstein Barr virus (EBV) or any severe infection that needs treatment
• have another medical condition or mental health problem that your doctor or the trial team think could affect you taking part

Other
You can’t join this trial if any of these apply. You:

• have had a live vaccine  in the last 4 weeks or you might need one during the trial. The current approved COVID-19 vaccines are not live.
• are allergic to tiragolumab, atezolizumab, pembrolizumab or anything they contain 
• are pregnant or breastfeeding