“Deborah agreed to take part in a trial as she was keen to help other cancer patients in the future. "If taking part in a trial means others might be helped then I’m very happy with that."
A trial of AZD4547 for breast cancer that got worse despite hormone therapy (RADICAL)
This trial looked at a drug called AZD4547 alongside anastrozole or letrozole for breast cancer that got worse despite hormone therapy. It was for women with oestrogen receptor positive (ER positive) breast cancer.
This trial was supported by Cancer Research UK.
More about this trial
Hormone therapy is a common treatment for women with ER positive breast cancer. Anastrozole and letrozole are hormone therapy drugs that are a common treatment for breast cancer. But sometimes, they stop working. Doctors describe this as becoming
You usually have treatment with another hormone therapy drug if this happens. But doctors are looking for new ways to help women in this situation.
In this trial, they looked at a drug called AZD4547 to see if women can benefit from taking anastrozole or letrozole again.
AZD4547 is a type of targeted cancer drug called a cancer growth blocker. It stops signals that cancer cells use to divide and grow.
The main aim of this trial was to find out how well AZD4547 with anastrozole or letrozole works as a treatment so that women can benefit from these hormone therapies again.
Summary of results
The trial team concluded that AZD4547 with anastrozole or letrozole helps women with ER positive breast cancer.
This was a phase 1/2 trial. 58 women with advanced breast cancer took part.
Everyone had treatment with AZD4547 and 1 of following drugs:
- anastrozole (Arimidex)
- letrozole (Femara)
The dose of AZD4547 women had depended on when they joined the trial. Everyone had treatment for as long as their cancer shrunk, stayed the same or didn’t get worse. When their cancer got worse (
The trial team looked at how well AZD4547 worked for the women after 12 weeks of treatment and again at 28 weeks.
To do this they looked at the number of women whose cancer stayed the same (
After 12 weeks of treatment, they found that out of the 52 women:
- 1 woman had a partial response
- 18 women had stable disease
And after 28 weeks of treatment, they found that out of the 52 women:
- 2 women had a partial response
- 11 women had stable disease
The team also looked at the average length of time women lived without any signs of their cancer getting worse. Doctors call this progression free survival. They found that on average, women lived around 3 months without any signs of their cancer getting worse.
The research team looked at the side effects women had. The team found that all the side effects were mild. The most common side effects were:
- high levels of phosphate in the blood
- hair loss (alopecia)
- taste changes
- constipation and diarrhoea
- feeling sick
The trial team concluded that AZD4547 with anastrozole or letrozole helps women with advanced breast cancer. They think this is a safe treatment.
The team thinks there should be more research looking for substances (
We have based this summary on information from the research team. As far as we are aware, the information they sent us has not been reviewed independently (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor Michael Seckl
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Imperial College London
NIHR Clinical Research Network: Cancer