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A trial looking at LY2495655 to treat muscle loss and weakness in people with advanced pancreatic cancer (JDDG)

Overview

Cancer types:

Pancreatic cancer

Status:

Closed

Phase:

Phase 2

Details

This trial is looking at a new drug called LY2495655 to treat muscle loss and weakness in people with pancreatic cancer that has spread into nearby tissue () or to another part of the body.

People with advanced cancer often have loss of muscle and muscle weakness. Currently there is no treatment for this. This trial is looking at a drug called LY2495655 to help stop muscle loss and weakness.

LY2495655 works by blocking a substance (protein) called myostatin. Myostatin controls muscle growth in the body. By blocking it, the researchers hope LY2495655 will help control muscle loss and weakness.

The researchers will be looking at LY2495655 in combination with chemotherapy for advanced pancreatic cancer. The trial drug will not be treating the cancer itself.

The aims of this trial are to find out

  • How safe LY2495655 is

  • What are the side effects are when you have it with chemotherapy

Recruitment start: 22 November 2012

Recruitment end: 20 December 2013

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Kenneth Fearon

Supported by

Eli Lilly and Company Limited

Experimental Cancer Medicine Centre (ECMC)

National Institute for Health Research Cancer Research Network (NCRN)

Last reviewed: 23 November 2015

CRUK internal database number: 9280

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