A trial looking at MK-3475A for non small cell lung cancer (MK3475A-F84)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have squamous cell  or non squamous cell non small cell lung cancer (NSCLC) that has spread to another part of the body. Your doctor will know this. 
• have a biomarker  called PD-L1 in more than half of your cancer cells 
• have an area of cancer that your doctor can measure on a scan
• have satisfactory blood test results 
• are willing to use reliable contraception during the trial and for a period after if there is any chance you or your partner could become pregnant 
• are fit and active but might not be able to do heavy physical work (performance status 0 or 1)
• are at least 18 years old 

Who can’t take part

Cancer related 
You cannot join this trial if any of these apply. You:

• have small cell lung cancer or a mixture of small cell and non small cell cancer cells
• have a change (mutation ) in the EGFR gene, the ALK gene or the ROS1 gene in your lung cancer cells. This means you are suitable for a specific treatment. Your doctor will know this. 
• have cancer that has spread to the brain or spinal cord or the thin tissue layers that cover them. You can take part if you have had treatment, the cancer is stable and you have stopped taking steroids.
• have already had treatment to the whole body for NSCLC that has spread to another part of the body. You can take part if you have had chemotherapy, radiotherapy or both before surgery for NSCLC that hadn’t spread and you finished this treatment within 12 months of being diagnosed with metastatic NSCLC.
• have had an immunotherapy  or a similar treatment in the past. Your doctor will know this.
• have had any other cancer treatment to the whole body within 4 weeks of starting trial treatment 
• have had radiotherapy within 2 weeks of starting trial treatment or you have side effects from radiotherapy and need to have steroids
• have had radiotherapy to the lung that is more than 30 Gray  within 6 months of starting trial treatment. Your doctor will know this. 
• have side effects from other cancer treatments that are causing you problems and the trial team think that this could prevent you from taking part
• have had another cancer that is getting worse or needed treatment in the last 3 years. You can join if you had successfully treated non melanoma skin cancer  or carcinoma in situ . You can’t take part if you have carcinoma in situ of the bladder. You might be able to take part if you have early prostate cancer.
• are taking an experimental drug or using a device as part of another clinical trial. This is if it is within 4 weeks of joining this trial. 

Medical conditions 
You cannot join this trial if any of these apply. You:

• have a problem with how your immune system  works or you had treatment that damps down the immune system. This includes steroids within 1 week of starting trial treatment unless it was a low dose. 
• have or had an autoimmune condition  that needed treatment in the last 2 years apart from certain ones. Your doctor will know about this. 
• had scarring on the lungs or  inflammation of the lungs (pneumonitis ) that needed steroid treatment or you have either of these conditions 
• have HIV, a hepatitis B infection in the past, an active hepatitis C infection or you have another infection that needs treatment
• have had a stem cell transplant  with somebody else’s cells or you have had an organ transplant
• haven’t recovered from major surgery or you have ongoing complications from surgery
• have another medical condition, mental health condition or the trial doctor thinks there is another reason that could affect you taking part 

Other
You cannot join this trial if any of these apply. You:

• have had a live vaccine  within 30 days of the start of treatment. Please note that the COVID-19 vaccine is allowed as it isn’t a live vaccine.
• are allergic to pembrolizumab, MK-5180 (hyaluronidase) or anything they contain 
• are pregnant or breastfeeding