
"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
This trial tried to find out if it was better to start diethylstilbestrol straight after having treatment for prostate cancer that had spread or later on.
When prostate cancer spreads outside of the prostate gland, or to elsewhere in the body, it may be treated with hormone therapy. But it can continue to grow despite this treatment.
One treatment doctors may use is a combination of dexamethasone, aspirin and diethylstilbestrol. Dexamethasone is a steroid, aspirin is a type of anti inflammatory drug and diethylstilbestrol is a type of hormone therapy.
We know from earlier studies that these drugs can lower the level of a substance in the blood called the prostate specific antigen (PSA). This can be measured by a blood test. Doctors use PSA test results to follow the progress of treatment for some men with prostate cancer. If the PSA level is raised at diagnosis, it often comes down again when treatment has started to work.
Doctors have found that more than half of the men who have dexamethasone, aspirin and diethylstilbestrol have a drop in their PSA level. This means that the cancer has stopped growing or is not growing as quickly.
The researchers of this trial wanted to improve on this. They wanted to find out if it was better to start diethylstilbestrol straight away with dexamethasone and aspirin, or at a later stage.
The aims of this trial were to find out if delaying the start of diethylstilbestrol
The trial team found that there was not much difference between starting diethylstilbestrol straight after treatment and delaying it.
Of the 270 men recruited everyone had dexamethasone and aspirin
The researchers found no significant difference between the 2 groups when they looked at
The side effects of diethylstilbestrol were
The trial team concluded that starting diethylstilbestrol straight away did not control prostate cancer better than delaying it.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists () but may not have been published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Jonathan Shamash
Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Orchid Cancer Appeal
Queen Mary University of London
Freephone 0808 800 4040
"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”