Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A study looking at treatment outcomes of pazopanib for advanced kidney cancer (PRINCIPAL)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
The researchers want to find out more information about how well pazopanib works and how it affects
Taking part in this study will not affect your treatment, as your doctor will be prescribing this drug for you whether or not you join the study. But the information they gather from the study may help doctors learn more about pazopanib.
Who can enter
You may be able to enter this trial if
- You have renal cell cancer that is mostly clear cell type and has spread to another part of your body
- Your doctor has decided to treat your cancer with pazopanib and you start treatment within a month of agreeing to take part in this study
- You are at least 18 years old
You cannot enter this trial if you
- Are already having treatment as part of another clinical trial
- Have already had treatment for your advanced kidney cancer with a drug that blocks cancer growth signals (such as sunitinib or everolimus), or a drug that blocks the growth of blood vessels to the cancer, for example bevacizumab
You take pazopanib as directed by your doctor.
For 2½ years your doctor will send information about your health and medications to the study team.
The study team will ask you to fill out 3 questionnaires when you first agree to take part in this study, and then every 3 months for 2½ years. These questionnaires will ask about side effects and how you’ve been feeling. This is called a quality of life study.
There are no extra visits if you take part in this study.
The most common side effects of pazopanib are
- Rash or red, itchy, dry skin
- Tiredness (fatigue)
- Hair colour changes and hair thinning
- Feeling or being sick (nausea)
- High blood pressure
- A drop in blood cells causing an increased risk of bleeding
- Loss of appetite and taste changes
- Stomach ache
How to join a clinical trial
Prof Robert Hawkins
NIHR Clinical Research Network: Cancer