A study looking at how to test the genes in lung cancer cells (Stratified Medicine Programme Two - SMP2)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer
Non small cell lung cancer





This study is looking at how to test for changes in the genes of lung cancer cells.

It is part of the Cancer Research UK Stratified Medicine Programme.

More about this trial

Currently doctors decide on how to treat a cancer by looking at

  • What type of cancer it is
  • Where it is in your body
  • The size of cancer
  • What the cancer cells look like

We know that this works for many people but not for all. This could be because there are slight differences in the cancer cells from person to person even if they have the same type of cancer. So researchers have been looking in detail at the differences between cancer cells. They've found that some cancer cells have particular proteins in the cell and others don’t. Or sometimes cancer cells have far more of a particular protein than healthy cells. These differences between cells are caused by changes to the genes in the cancer cells.

Researchers want to look at a way to test for these genetic changes. They hope that in the future doctors may be better able to match treatment to the changes in the genes of cancer cells. This is called stratified medicine.

To do this, the researchers need to collect samples of cancer tissue from a large number of lung cancer patients and test them for genetic changes. And to gather information about what treatment they have and what happens to them. We also use this information to find out whether these patients would be eligible for a large clinical trial called the National Lung Matrix trial

The researchers also want to find out what the costs are to do this and how best it can be used as a part of routine care in the future.

Who can enter

You may be able to enter this trial if you have non small cell lung cancer.

Trial design

This part of the study aims to recruit around 100 people every month from around the UK.

The research team will ask for a small piece of tissue taken when you have surgery. If you are not having surgery they can take a sample of tissue removed when you had a biopsy. 

They will also ask your permission to look at your medical notes and other health related records to find out about

  • Your cancer
  • Other illness you may have
  • Your treatment now and in the future

Hospital visits

There are no extra side effects if you join this trial. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Charlie Swanton

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

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"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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