
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at changes in ovarian cancer cells when women have a drug called GSK2110183. This study is for women who are taking part in a trial of GSK2110183 with chemotherapy for ovarian cancer.
GSK2110183 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow.
In this study the researchers want to identify and measure the changes that GSK2110183 causes in cancer cells. To do this, they will take blood samples and tissue samples from women before they start treatment with GSK2110183 and afterwards.
They hope that their research will help predict who may benefit from having treatment. And that future treatment could be better tailored for individual women.
Please note – You won’t get any direct benefit from taking part in this study, nor will it affect any treatment you have. But it may help patients in the future.
You may be able to enter this trial if you are taking part in a trial of GSK2110183 with chemotherapy for ovarian cancer and
You cannot enter this trial if you are taking warfarin or low molecular weight heparin to stop your blood clotting.
This study will recruit 30 people who are also taking part in a trial of GSK2110183 with chemotherapy for ovarian cancer.
When you have blood tests in the trial, extra blood samples will be taken at the same time for this study.
You have a tissue sample () of your cancer taken once before you start treatment. The researchers will also ask for a 2nd tissue sample 3 weeks after starting treatment. You don’t have to have the 2nd sample taken.
The researchers will also ask for a sample of your cancer that was removed when you had surgery or a previous biopsy.
If you need to have fluid drained from around your tummy (abdomen), the researchers will take a sample of the fluid.
The researchers will use these samples to find out how GSK2110183 works. They will also use them to develop tests to try and predict who may benefit from this treatment.
You go to the hospital to have the tissue samples taken.
You may have some bruising or bleeding after giving blood samples and tissue samples.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Sarah Blagden
Experimental Cancer Medicine Centre (ECMC)
Imperial College London
NIHR Clinical Research Network: Cancer
Ovarian Cancer Action
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.