A study looking at tissue samples of lung cancer (PaBLuc)

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Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Lung cancer
Small cell lung cancer





This study is for people having their lung cancer treatment at the Royal Marsden Hospital. 

More about this trial

In this study before and during your treatment the team take blood samples and tissue samples (biopsies Open a glossary item). They compare the DNA Open a glossary item in the cells of each sample. 

The aims of the study are to:

  • look for the differences in the DNA of cancer cells before and after treatment
  • find why cancers behave differently after treatment 

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

You may be able to join this study if all of the following apply. You:

  • have cancer that has spread into the surrounding tissue or to another part of the body (stage 3 or stage 4)
  • have small cell lung cancer or a squamous cell Open a glossary itemlung cancer or adenocarcinoma Open a glossary itemof the lung with a known change (mutation) 
  • have an area of cancer that a small piece of tissue (biopsy) can be taken from
  • are having treatment that is intended to control your symptoms or provide support (palliative treatment Open a glossary item)
  • are at least 18 years old

You cannot join this study if your doctor thinks it’s not suitable for you. 

Trial design

This is a feasibility study. The researchers need 15 people who are having treatment at The Royal Marsden Hospitals to join. 

They will ask for a sample of tissue either from when you had a biopsy or surgery to diagnose your cancer. They will also take a blood sample.

You have biopsies and blood samples taken if your cancer gets worse. This might be before your first treatment or any later treatment. 

You have another 2 blood samples taken at the same time routine bloods are taken. 

You might be asked for another biopsy if your cancer grows again. You don’t have to have this one if you don’t want to. 

The study team will ask permission to look at your hospital notes.

Hospital visits

The first blood sample will usually be taken with your routine bloods. All other blood samples are taken with your routine bloods. 

A few days before your biopsy you will get information about when to stop eating and drinking. And what you should do about any regular medications you take.

You go to the hospital for the biopsy. You might have medication to make sleepy (a sedative) or local anaesthetic to numb the area. This depends on which biopsy you have.

You should expect to be there for about 6 hours. You should not need to stay overnight. 

Side effects

The most common risks of having a biopsy include:

  • pain from the site where the biopsy was taken
  • swelling
  • bruising or bleeding

Your doctor will talk to you about having a lung biopsy and any risks before you agree to take part. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Sanjay Popat

Supported by

Imperial College London
Institute of Cancer Research (ICR)
NIHR Royal Marsden Biomedical Research Centre 
Royal Brompton & Harefield NHS Foundation Trust
The Royal Marsden NHS Foundation Trust


Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

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"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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