A study looking at proteins called CTCF and BORIS as possible biomarkers for breast and prostate cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Breast cancer
Prostate cancer





This study is looking at proteins called CTCF and BORIS in blood and samples of tissue removed during surgery.

Researchers are looking for substances in the body that can help them to diagnose cancer, and to work out how well people are likely to respond to treatment. These substances are called biomarkers Open a glossary item.

In this study, they are trying to find out how useful proteins called CTCF and BORIS would be as biomarkers for breast cancer and prostate cancer. The researchers will study blood samples from people with breast or prostate cancer and also samples of breast or prostate tissue removed during surgery.

They want to look at samples from people who are diagnosed with cancer, as well as samples from people who do not have cancer. So being asked to take part in this study does not mean you have cancer.

Please note - you won’t get any direct benefit from taking part in the study, nor will it affect any treatment you may need to have. It is possible that the findings may help people in the future.

Who can enter

You can enter this trial if you are a man having prostate surgery or a woman having breast surgery at Colchester General Hospital or Essex County Hospital. People are usually invited to join this trial, but you can also volunteer.

Trial design

The study team will keep some of the tissue removed when you have surgery. They will also take a small blood sample. They will use these samples to study proteins called CTCF and BORIS.

Taking part in the study does not involve having any extra tissue removed. Your surgeon will only remove the necessary amount of tissue to make a diagnosis and see if you need to have treatment. The researchers will keep the tissue that is left over after all other tests you need have been done.

The samples will be anonymous, so the researchers will not know who you are. And they will not know any of your personal or medical details. The samples will not be used for anything other than this study and they will be destroyed after 5 years.

Hospital visits

Taking part in this study does not involve any extra hospital visits.

Side effects

There are no side effects associated with taking part in the study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Elena Klenova

Supported by

Association for International Cancer Research (AICR)
Breast Cancer Campaign
Cancer Research UK
Colchester Hospital University NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Essex

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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