"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
A study comparing MRI scan with PET-CT scan for cervical and womb cancer (MAPPING)
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Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is looking at comparing MRI scan and PET-CT scan for cervical cancer and womb (endometrial) cancer to see which is better in helping doctors see if cancer has spread, and how far. This trial is supported by Cancer Research UK.
Doctors often use MRI scan to find out how far cervical and endometrial cancer has spread. MRI scans are good but doctors are always looking for better ways to find out how far the cancer has spread. A PET-CT scan combines 2 scans, a PET scan using a radioactive tracer and a CT scan. The tracer is a radioactive injection that shows how far the cancer has spread.
The researchers think another type of MRI scan (DW MRI scan) or a PET-CT scan may be better than a standard MRI scan. The researchers will also look at 2 different radioactive tracers used for the PET-CT scan.
The researchers want to compare the standard MRI scan with the DW MRI scan and PET-CT scan to find out which is better at showing how far cervical and endometrial cancer has spread.
Who can enter
You may be able to enter this study if you have either
- Cervical cancer that is stage 1B1 or higher
- Endometrial cancer that has spread into the muscle layer of the uterus or further (Stage 1A or higher) and has very abnormal cells (grade 3) or is mixed mullerian or papillary serous type or clear cell type or is stage 2 or higher that is any grade
- You are having surgery to remove your lymph nodes
- You and your partner are willing to use reliable contraception if there is any chance you could become pregnant
- You are at least 18 years old
You cannot enter this study if you
- Can’t have surgery to remove your lymph nodes
- Can’t have a MRI scan for example you have a pacemaker or metal in your body or you cannot cope with being in a small space
- Can’t have a PET-CT scan
- Are having an experimental drug as part of another clinical trial
- Are due to have scans as part of another clinical trial at the same time as the scans for this study
- Have a medical condition that could affect you taking part in this study
- Are pregnant or breastfeeding
This is a phase 2 study. It will recruit up to 150 women. Everyone taking part will have a
- MRI scan
- DW MRI scan
- PET-CT scan
The researchers will ask you if you are willing to have another PET-CT scan using a different radioactive tracer.
After your scans your doctor will talk to you about surgery.
You have 2 or 3 extra visits to the hospital for the extra scans.
If you are having the 2nd PET-CT scan you may need to visit another hospital.
You shouldn’t have any side effects from having the MRI scan.
You will be exposed to a little extra radiation by having the study PET-CT scan. We are all exposed to a very small amount of radiation during the course of a normal day (background radiation). The amount of radiation you would have from the extra CT scan is about the same as several years of background radiation, and is thought to be low risk.
How to join a clinical trial
Prof Andrea Rockall
Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
Cancer Research UK
NIHR Clinical Research Network: Cancer