A study looking at a new chemotherapy plan for men with testicular cancer called seminoma that has spread (CarPET)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Testicular cancer




Phase 2

This study is looking at replacing BEP chemotherapy with high dose carboplatin chemotherapy to treat seminoma. It is also looking at PET-CT scans to assess early response to treatment.

If you have a type of testicular cancer called seminoma, and this has spread to your lungs, you usually have a course of BEP chemotherapy.  This is a combination of the drugs bleomycin, etoposide and cisplatin.  You have these drugs every 21 days for up to 4 cycles of treatment, staying in hospital for about a week each time.

Some of the side effects of BEP can become long term problems. Doctors would like to reduce side effects, and the time it usually takes to give each treatment. In this study, they want to see if giving a drug called carboplatin at a higher dose than usual would work as well as the BEP combination of chemotherapy. Carboplatin has fewer side effects than the combination of BEP drugs. You have carboplatin once every 3 weeks in the same way as BEP, but the treatment only takes about an hour each cycle. So you would also spend much less time in hospital.

The team also want to see if having a PET-CT scan before and after your first cycle of treatment will help them to assess any early response to treatment more accurately. They want to see if this works better than a standard CT scan.

The main aims of this study are to

  • Learn more about the safety and side effects of high dose carboplatin
  • See how well it works to treat seminoma
  • See if using PET-CT scans can help spot an early response to carboplatin better than standard CT scans, leading to fewer men needing 4 cycles of carboplatin

Who can enter

You may be able to enter this study if

  • You have a type of testicular cancer called a seminoma Open a glossary item, and this has spread to your lungs
  • Your doctors think there is a good chance that they can successfully treat your cancer
  • You have satisfactory blood test results
  • A blood or urine test shows that your kidneys are working well enough to flush out the chemotherapy
  • You are willing to use reliable contraception during and after the study if there is any chance that your partner could become pregnant
  • You are between 18 and 75 years old

You cannot enter this study if

  • Your cancer has spread to anywhere other than to your lungs
  • You have had any other cancer apart from basal cell skin cancer
  • You are in a bed or chair all the time and need a lot of looking after (you have a performance status of 4)
  • You have had chemotherapy or radiotherapy before
  • You are taking part in another clinical trial looking at an experimental drug

Trial design

This study will recruit 50 men. Everyone taking part has carboplatin chemotherapy.

You have carboplatin through a drip into a vein, over about an hour. You have it once every 3 weeks. Each 3 week period is called a cycle of treatment. You can have up to 4 cycles of treatment. The number of cycles you have depends on results from scans you have to see how well the carboplatin is working.

If the scans show that your cancer is not responding to carboplatin, you may have standard chemotherapy Open a glossary item or surgery. These treatments are not part of the study.

CarPET study diagram


Hospital visits

Before you start treatment you see the study doctor and have some tests.  These tests include

  • Physical examination
  • Blood tests
  • CT scan (if needed)
  • PET-CT scan

You visit the hospital once every 3 weeks to have carboplatin chemotherapy.  You will make up to 4 visits for this altogether, depending on how your cancer responds.

You will have a number of PET-CT scans and CT scans during your treatment, and after you finish the study. The number and type of scans you have will depend on how your cancer responds to carboplatin. The study team will be able to tell you more about this.  

Side effects

Side effects of carboplatin include

You can find out more about carboplatin in our cancer drugs section.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Jonathan Shamash

Supported by

Barts Health NHS Trust
Experimental Cancer Medicine Centre (ECMC)
Orchid Clinical Trials Group

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 5949

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Ashley was diagnosed with testicular cancer when he was 28

A picture of Ashley

"I now know how cancer can strike anyone whatever their situation or circumstance. I hope by taking part in a trial it will help others in my position in the future.”

Last reviewed:

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