Acute lymphoblastic leukaemia (ALL) incidence statistics

Cases

New cases of acute lymphoblastic leukaemia, 2015, UK

 

Proportion of all cases

Percentage acute lymphoblastic leukaemia is of total cancer cases, 2015, UK

 

Age

Peak rate of acute lymphoblastic leukaemia cases, 2013-2015, UK

Trend over time

Acute lymphoblastic leukaemia incidence rates have remained stable since the early 1990s, UK

Acute lymphoblastic leukaemia is not among the 20 most common cancers in the UK, accounting for less than 1% of all new cancer cases (2015).[1-4]

In males in the UK, acute lymphoblastic leukaemia is not among the 20 most common cancers (less than 1% of all new male cancer cases). In females in the UK it is not among the 20 most common cancers (less than 1% of all new female cancer cases).

55% of acute lymphoblastic leukaemia cases in the UK are in males, and 45% are in females.

Acute lymphoblastic leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item ) are similar to the UK average in all the UK constituent countries.

Acute Lymphoblastic Leukaemia (C91.0), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2015

  England Scotland Wales Northern Ireland UK
Male Cases 381 41 24 14 460
Crude Rate 1.4 1.6 1.6 1.5 1.4
AS Rate 1.3 1.6 1.6 1.3 1.3
AS Rate - 95% LCI 1.2 1.1 1.0 0.6 1.2
AS Rate - 95% UCI 1.4 2.0 2.2 2.0 1.4
Female Cases 310 31 19 12 372
Crude Rate 1.1 1.1 1.2 1.3 1.1
AS Rate 1.1 1.1 1.2 1.2 1.1
AS Rate - 95% LCI 0.9 0.7 0.6 0.5 1.0
AS Rate - 95% UCI 1.2 1.5 1.7 1.9 1.2
Persons Cases 691 72 43 26 832
Crude Rate 1.3 1.3 1.4 1.4 1.3
AS Rate 1.2 1.3 1.4 1.3 1.2
AS Rate - 95% LCI 1.1 1.0 0.9 0.8 1.1
AS Rate - 95% UCI 1.3 1.6 1.8 1.7 1.3

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item  around the AS Rate Open a glossary item
 

For acute lymphoblastic leukaemia, there are few established risk factors therefore differences between countries largely reflect differences in diagnosis and data recording.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2015, ICD-10 C91.0.

Last reviewed:

Acute lymphoblastic leukaemia incidence is strongly related to age, with the highest incidence rates being in the 0 to 04 age group. In the UK in 2013-2015, on average each year around 5 in 100 (6%) of new cases were in people aged 75 and over.[1-4] In contrast to most cancer types, acute lymphoblastic leukaemia occurs most frequently at younger ages.

Age-specific incidence rates are highest in infants aged 0-4 and drop sharply through childhood, adolescence and young adulthood, reaching their lowest point at age 30-34 in males and 35-39 in females, and increasing slightly thereafter. The highest rates are in the 0 to 04 age group for males and females.

Incidence rates are significantly higher in males than females in a few (mainly younger) age groups. The gap is widest at age 35 to 39, when the age-specific incidence rate is 2.8 times higher in males than females.

Acute Lymphoblastic Leukaemia (C91.0), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2013-2015

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item
 

For acute lymphoblastic leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2013-2015, ICD-10 C91.0.

Last reviewed:

Acute lymphoblastic leukaemia European age-standardised (AS) Open a glossary item incidence rates for males and females combined remained stable in the UK between 1993-1995 and 2013-2015.[1-4] The rate remained stable in both males and females.

For males, acute lymphoblastic leukaemia AS incidence rates in the UK remained stable between 1993-1995 and 2013-2015. For females, acute lymphoblastic leukaemia AS incidence rates in the UK remained stable between 1993-1995 and 2013-2015.

Over the last decade in the UK (between 2003-2005 and 2013-2015), acute lymphoblastic leukaemia AS incidence rates for males and females combined remained stable. In males AS incidence rates remained stable, and in females rates remained stable.

Acute Lymphoblastic Leukaemia (C91.0), European Age-Standardised Incidence Rates, UK, 1993-2015

Acute lymphoblastic leukaemia incidence rates have remained stable overall in most broad age groups in males and females combined in the UK since the early 1990s, but have decreased in some.[1-4] Rates in 0-24s have remained stable, in 25-49s have remained stable, in 50-59s have remained stable, in 60-69s have remained stable, in 70-79s have remained stable, and in 80+s have decreased by 35%.

Acute Lymphoblastic Leukaemia (C91.0), European Age-Standardised Incidence Rates, By Age, UK, 1993-2015

For acute lymphoblastic leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2015, ICD-10 C91.0.

Last reviewed:

There is evidence for a small association between acute lymphoblastic leukaemia (ALL) incidence and deprivation for males in England, making this one of the few cancers where incidence rates are lower for more deprived males. There is no evidence for an association between the incidence of ALL and deprivation for females.[1]

England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are 14% lower for males living in the most deprived areas compared with the least deprived, but for females the rates are similar for those living in the least and most deprived areas.[1]

Acute Lymphoblastic Leukaemia (C91.0), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

For males diagnosed with acute lymphatic leukaemia the deprivation gradient has gone from having higher incidence in the more deprived in 1996-2000 to having higher incidence rates in the less deprived in 2006-2010. The estimated deprivation gradient  in acute lymphatic leukemia incidence for females living in the most and least deprived areas in England has not changed in the period 1996-2020.

References

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014

About this data

Data is for: England, 2006-2010, ICD-10 C91.0

Deprivation gradient statistics were calculated using incidence data for three time periods: 1996-2000, 2001-2005 and 2006-2010. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

An estimated 8,200 people who had been diagnosed with acute lymphoblastic leukaemia (ALL) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991 and 2010) and Northern Ireland (1993-2010), ICD-10 C91.0.

Last reviewed:

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