Chronic lymphocytic leukaemia (CLL) incidence statistics

Cases

New cases of chronic lymphocytic leukaemia, 2013, UK

 

Proportion of all cases

Percentage chronic lymphocytic leukaemia is of total cancer cases, 2013, UK

 

Age

Age that around 6 in 10 of chronic lymphocytic leukaemia cases are diagnosed, 2011-2013, UK

 

Trend since 1970s

Chronic lymphocytic leukaemia incidence rates have increased since the late 1970s, GB

Chronic lymphocytic leukaemia (CLL) accounts for 1% of all new cancer cases in the UK, and 37% of all leukaemia types combined (2013).[1-4]

In 2013, there were 3,442 new cases of CLL in the UK: 2,164 (63%) in males and 1,278 (37%) in females, giving a male:female ratio of around 17:10.[1-4] The crude incidence rate Open a glossary item shows that there are 7 new CLL cases for every 100,000 males in the UK, and 4 for every 100,000 females.

European age-standardised incidence rates Open a glossary item (AS rates) are significantly higher in England and Wales compared with Scotland and Northern Ireland for both males and females.[1-4] There are no other significant differences in rates between the constituent countries of the UK. Differences in registration methods, diagnosis and classification are likely to have a bearing on comparisons between the countries, as there is no evidence of variation on aetiological factors within the UK.[5]

Chronic Lymphocytic Leukaemia (C91.1), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2013

England Wales Scotland Northern Ireland UK
Male Cases 1,884 138 114 28 2,164
Crude Rate 7.1 9.1 4.4 3.1 6.9
AS Rate 8.7 9.8 5.3 4.2 8.3
AS Rate - 95% LCL 8.3 8.1 4.3 2.6 8.0
AS Rate - 95% UCL 9.1 11.4 6.2 5.7 8.7
Female Cases 1,098 91 71 18 1,278
Crude Rate 4.0 5.8 2.6 1.9 3.9
AS Rate 4.2 5.4 2.6 2.3 4.0
AS Rate - 95% LCL 3.9 4.3 2.0 1.2 3.8
AS Rate - 95% UCL 4.4 6.5 3.2 3.3 4.3
Persons Cases 2,982 229 185 46 3,442
Crude Rate 5.5 7.4 3.5 2.5 5.4
AS Rate 6.2 7.5 3.8 3.1 6.0
AS Rate - 95% LCL 6.0 6.5 3.2 2.2 5.8
AS Rate - 95% UCL 6.4 8.4 4.3 4.0 6.2

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
  5. Haematological Malignancy Research Network. Haematological malignancies & cancer registration in England (2004-2008). Quality appraisal comparing data from the National Cancer Data Repository (NCDR) with the population-based Haematological Malignancy Research Network (HMRN). Final Report. London: Leukaemia Lymphoma Research; 2012.
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CLL incidence is strongly related to age, with the highest incidence rates being in older males and females. In the UK in 2011-2013, on average each year around 6 in 10 (59%) cases were diagnosed in people age 70 and over.[1-4]

Age-specific incidence rates rise sharply from around age 45-49, with the highest rates in the 90+ age group. Incidence rates are higher for males than for females aged 15-19 and aged 45-49 and over (with no significant difference in most younger groups), and this gap is widest at the age of 45-49, when the male:female incidence ratio of age-specific rates (to account for the different proportions of males to females in each age group) is around 22:10.[1-4]

Chronic Lymphocytic Leukaemia (C91.1), Average Number of New Cases per Year and Age-Specific Incidence Rates, UK, 2011-2013

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
Last reviewed:

Chronic lymphocytic leukaemia (CLL) incidence rates have increased by 71% in Great Britain since the late 1970s.[1-3] This includes a larger overall increase for females than for males, though for both sexes rates have stabilised in recent years.

For males, European age-standardised Open a glossary item (AS) incidence rates increased 60% between 1979-1981 and 2000-2002 and have since remained stable – leaving rates in 2011-2013 59% higher than those in 1979-1981. For females, rates increased by 69% between 1979-1981 and 2000-2002 and have since remained stable – leaving rates in 2011-2013 68% higher than those in 1979-1981.

Chronic Lymphocytic Leukaemia (C91.1), European Age-Standardised Incidence Rates, Great Britain, 1979-2013

Over the last decade in the UK (between 2002-2004 and 2011-2013), CLL incidence rates have remained stable for males and females combined and separately.[1-4]

Chronic Lymphocytic Leukaemia (C91.1), European Age-Standardised Incidence Rates, UK, 1993-2013

CLL incidence trends probably reflect improvements in diagnostic techniques and data registration.[5,6]

CLL incidence rates have increased overall for all the broad age groupsin Great Britain since the late 1970s.[1-3] For all of these age groups this has included an increase followed by a period of stability. The largest increase has been in people aged 25-49, with European AS incidence rates doubling (101% increase) between 1979-1981 and 2011-2013. The smallest increase has been in people aged 80+, with European AS incidence rates rising by 41% between 1979-1981 and 2011-2013.

Chronic Lymphocytic Leukaemia (C91.1), European Age-Standardised Incidence Rates, by Age, Great Britain, 1979-2013

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/
  5. Northern and Yorkshire Cancer Registry and Information Service. Haematological malignancies in England. Cancers Diagnosed 2001-2008. London: NCIN; 2013
  6. National Cancer Data Repository (NCDR). Blood Cancers Data Quality Report 2010. London:NCIN.
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The lifetime risk of developing chronic lymphocytic leukaemia (CLL) is around 1 in 155 for men and around 1 in 260 for women, in 2012 in the UK.[1]

The lifetime risk for CLL has been calculated on the assumption that the possibility of having more than one diagnosis of CLL over the course of a lifetime is very low (‘Current Probability’ method).[2]

References

  1. Lifetime risk estimates calculated by the Statistical Information Team at Cancer Research UK. Based on data provided by the Office of National Statistics, ISD Scotland, the Welsh Cancer Intelligence and Surveillance Unit and the Northern Ireland Cancer Registry, on request, December 2013 to July 2014.
  2. Esteve J, Benhamou E and Raymond L. Descriptive epidemiology. IARC Scientific Publications No.128, Lyon, International Agency for Research on Cancer, pp 67-68 1994.
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There is no evidence for an association between chronic lymphocytic leukaemia (CLL) incidence and deprivation for either males or females in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item incidence rates are similar for both males and females living in the most deprived areas compared with the least deprived.[1]

Chronic Lymphocytic Leukaemia (C911), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in CLL incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

Last reviewed:

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