A trial looking at a vaccine to treat children with a type of brain tumour called a high grade glioma

Cancer type:

Brain (and spinal cord) tumours
Children's cancers




Phase 1

This trial looked at making personalised vaccines Open a glossary item to see if they could stimulate the immune system to kill brain tumour cells.

More about this trial

This trial was for children between the ages of 3 and 18. We use the term ‘you’ in this summary, but if you are a parent we are referring to your child.

If you have a type of brain tumour called a glioma, and the tumour cells are fast growing (high grade), your treatment may include

In this trial, doctors wanted to see if adding a vaccine to treatment boosted the immune system to kill more brain tumour cells.

The aims of this trial included

  • Seeing how possible it is to make and give these vaccines to children
  • Learning more about the safety of the vaccines
  • Finding out whether adding this vaccine to standard treatment Open a glossary item helps stimulate the immune system


Summary of results

There were no results in this trial. The trial doctors said that they found the trial was not practical or possible to complete. 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr John Anderson

Supported by

Experimental Cancer Medicine Centre (ECMC)
Great Ormond Street Hospital for Children NHS Foundation Trust
Institute of Child Health
Royal Free London NHS Foundation Trust

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Last review date

CRUK internal database number:

Oracle 9697

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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