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A trial of olaparib for advanced prostate cancer that has got worse after standard treatment (TOPARP)

Overview

Cancer types:

Prostate cancer, Secondary cancers

Status:

Results

Phase:

Phase 2

Details

This trial looked at olaparib for men with prostate cancer that had spread elsewhere in the body. The men taking part had cancer that got worse despite hormone therapy and chemotherapy drugs called .

Cancer Research UK supported this trial.

The trial was open for people to join between 2012 and 2018. The team published results of the first part of the trial (TOPARP A) in 2015 and further results of the second part of the trial (TOPARP B) in 2020.

Recruitment start: 4 July 2012

Recruitment end: 19 June 2018

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Johann De Bono

Supported by

AstraZeneca

Cancer Research UK

Experimental Cancer Medicine Centre (ECMC)

Institute of Cancer Research (ICR)

NIHR Clinical Research Network: Cancer

The Royal Marsden NHS Foundation Trust

Prostate Cancer UK

The Prostate Cancer Foundation

Other information

This is Cancer Research UK trial number CRUK/11/029

Last reviewed: 18 January 2021

CRUK internal database number: 7399

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