Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial looking at treating anaemia before surgery for bowel cancer
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is comparing 2 different iron supplements for people with a low red blood cell count (anaemia) due to bowel cancer (colorectal cancer).
Doctors want to look at a new iron supplement injection to find out if it can reduce the amount of blood transfusions needed.
The aims of this trial are to find out
- If an iron supplement injection can reduce blood transfusions
- If the iron supplement injection is better than iron tablets
- About the side effects
Who can enter
You may be able to enter this trial if you
- Have bowel cancer
- Have low red blood cells (anaemia) but do not need a blood transfusion
- Are able to have surgery for your bowel cancer
- Are at least 18 years old
You cannot enter this trial if
- You need emergency surgery in the next 2 weeks
- You have raised iron levels in your blood - your doctor can tell you this
- You have had major bowel surgery in the past
- You have anaemia not caused by your cancer
- You are having chemotherapy
- You are allergic to iron supplements
- Your liver or kidneys are not working properly
- You have any condition that would make it unsafe for you to take part in this trial
- You have had medication as part of another trial in the last 12 weeks
- You are going to donate blood during the trial
- You are pregnant of breast feeding
This trial will recruit 116 people from the UK. This is a randomised trial. The people taking part are put into 2 treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
People in group 1 have iron (ferrous sulphate) tablets. You start taking these at least 14 days before your surgery.
People in group 2 have an iron supplement called ferinject. You have ferinject through a drip into a vein at least 2 weeks before your surgery.
The trial team will ask you to fill out questionnaires
- Before you start treatment
- Just before your surgery
- Between 6 and 12 weeks after surgery
This is called a quality of life study.
Taking part in this trial will not change the surgery you have. Your surgeon will discuss your operation with you.
If you agree to take part in this trial, the researchers will ask for a sample of tissue taken during the surgery to remove your cancer. They will use this to find out more about anaemia and cancer in the future. If you don’t want to give tissue samples for this study, you don’t have to. You can still take part in the trial.
You will see the doctors and have some tests before you start treatment. The tests include
- Physical examination
- Blood pressure recording
- Blood tests
You will have another blood test
- On the day of your operation
- A few days after your operation
- And 6 to 12 weeks later
This is the end of your participation in the trial.
The most common side effects of ferinject are
- Feeling dizzy
- Feeling and being sick
- A rash
- Stomach ache
The most common side effects of ferrous sulphate are
- Upset stomach
- Black stools
There is more information about surgery for bowel cancer.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Mr Austin Acheson
NIHR Clinical Research Network: Cancer
NIHR Research for Patient Benefit (RfPB) Programme
Nottingham University Hospital NHS Trust