A trial looking at genetic factors in people having chemotherapy for bowel cancer

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Bowel (colorectal) cancer
Colon cancer
Rectal cancer





This trial is looking at the genetic material (DNA) of people who are having chemotherapy for advanced bowel cancer to see if it affects how well they respond to treatment.

Doctors often treat bowel cancer (colorectal cancer) with chemotherapy and surgery. Chemotherapy works very well for some people, but unfortunately not so well for others. There are a number of theories about why this happens, but no one is quite sure at the moment.

There is growing interest in how our genes affect the chance that we will get cancer in the first place, and how we will respond to treatment if we do. There is still a lot of work to be done, but doctors hope that in the future they will be able to tailor treatments according to each person’s genetic make up.

The aim of the trial is see if the researchers can identify any common factors or genetic faults in people who respond well to chemotherapy, compared to those who don’t.

Who can enter

You can enter this trial if you

Trial design

This trial will recruit between 600 and 800 patients who are having chemotherapy for bowel cancer that has spread to another part of the body.

A nurse will take a blood sample. The research team will also record information about how well the treatment works, including test results. All the information about you will be kept completely anonymous and confidential.

In the lab, the research team will take the genetic material (DNA) from your blood sample. They will analyse the DNA of all the people taking part, and try to find common factors that affect how well chemotherapy works.

The overall results of this trial will be analysed and published. You will not be told about your individual results. You won’t get any direct benefit from taking part in this trial. But researchers hope that the results will help future patients.

Hospital visits

A research nurse will visit you either at home or in the outpatient clinic to take a blood sample. He or she will also ask you questions about your own and your family’s medical history.

You will not have to make any extra trips to the hospital as a result of taking part in this trial.

Side effects

There are no side effects from taking part in this trial.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Angela Cox
Dr Maria Marples

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Weston Park Hospital Cancer Appeal fund

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle - 432

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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