A study to understand more about soft tissue sarcoma

Cancer type:

Soft tissue sarcoma





This study is looking at samples of confirmed and possible (suspected) soft tissue sarcomas to try to understand more about how they develop.

Soft tissue sarcomas are rare cancers that develop from the cells that make up soft tissue (for example, muscle and fat tissue). As soft tissue is present in all parts of the body, sarcomas can grow almost anywhere. Sarcomas often appear as a lump or swelling. But most lumps are not cancerous. Researchers want to look at the differences between cancerous and non cancerous (benign) lumps in various types of soft tissue, to understand more about how soft tissue sarcomas develop.

They will study tissue samples from people with sarcoma, or suspected sarcoma. They will look for and examine any abnormal molecules that may be in the tissue, including proteins and DNA. Where the team can collect suitable samples, they will use the tissue to develop cell lines. Cell lines are cells removed from the tissue that can continue to be grown in the laboratory. Cell lines will be useful for further studies, which may include testing and developing new drug treatments.

You will not have any direct benefit from taking part in this study, and it is unlikely to change your treatment plan in any way. But the result of the study will be used to help people with cancer in the future.

Who can enter

This study is only recruiting patients from Weston Park Hospital or The Royal Hallamshire Hospital in Sheffield. If you are suitable for the study, a member of your medical team will ask if you would like to take part. People taking part will

You cannot enter this study if you would not be able to communicate easily with the study team for any reason.

Trial design

This study will recruit 250 people.

Everyone taking part will give permission for the study team to

  • Store and use any spare tissue removed from surgery or biopsies you have had, or may have
  • Gather details about your medical history and current condition, from both you and your medical records
  • Check your medical records from time to time to update their database on your condition
  • Keep your tissue samples after this study to use for future research

Hospital visits

You will not need to make any extra hospital visits to take part in this study.

Side effects

You will not have any side effects as a result of taking part in this study.



Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Ali Ismail

Supported by

Experimental Cancer Medicine Centre (ECMC)
Sheffield Teaching Hospitals NHS Foundation Trust
Yorkshire Cancer Research

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Around 1 in 5 people take part in clinical trials

3 phases of trials

Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.

Last reviewed:

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