A study to set up a national biobank and database for mantle cell lymphoma

Cancer type:

Blood cancers
High grade lymphoma
Low grade lymphoma
Lymphoma
Non-Hodgkin lymphoma

Status:

Open

Phase:

Other

This study is to collect blood, spit (saliva) and tissue samples to set up a national biobank and database for mantle cell lymphoma. These samples will be stored in a central place where researchers can look at them(a biobank). 

More about this trial

Mantle cell lymphoma is a type of non Hodgkin lymphoma. It can be either 

  • Slow growing (low grade or indolent) 
  • Fast growing (high grade or aggressive)

Treatment will depend on what grade the lymphoma is. If it is high grade treatment needs to start straight away. If it is low grade treatment may not need to start straight away. 

In this study researchers will ask for tissue samples taken from when you were diagnosed with lymphoma. They will use these to look for substances (biomarkers Open a glossary item) that might help predict the different ways lymphoma may behave. 

They will also collect 

  • Blood samples
  • Spit samples 
  • Information from medical notes

They will use this to try and find out how to tell the difference between high grade and low grade mantle cell lymphoma when it is diagnosed and before treatment is started. 

You may not benefit from taking part in this study. The information gained from this study may benefit people who are diagnosed with mantle cell lymphoma in the future.  

Who can enter

You may be able to join this study if you have been newly diagnosed with mantle cell lymphoma and are at least 16 years old. 

Trial design

The researchers need 300 people to join. The researchers will a take blood samples and spit (saliva) samples before you start chemotherapy.

For the spit samples, you will spit into a little tube a number of times. To collect enough you may need to do this 10 to 15 times. 

The researchers will ask your permission to take some samples from the biopsy taken when you were diagnosed with lymphoma. They will also ask your permission to look at your hospital notes to collect information about your lymphoma and how it is being treated.

Hospital visits

The blood and spit samples will be collected when you attend one of your routine clinic appointments. So there are no extra hospital visits.

Side effects

There are no side effects if you agree to take part. 

Location

Bath
Bournemouth
Bristol
Burton on Trent
Canterbury
Carlisle
Cheltenham
Chester
Colchester
Cottingham
Darlington
Dartford
Devon
England
Epsom
Exeter
Great Yarmouth
Hampshire
Harrow
Hereford
Ipswich
Kent
Leeds
Leicester
Lincolnshire
Liverpool
London
Macclesfield
Maidstone
Manchester
Newcastle upon Tyne
Northampton
Norwich
Nottingham
Plymouth
Portsmouth
Romford
Salisbury
Sheffield
Shrewsbury
Sutton
Sutton in Ashfield
Taunton
Torbay
Truro
Wirral
Yeovil

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Simon Rule

Supported by

Bloodwise
Peninsula Clinical Trials Unit at Plymouth University
Plymouth Hospitals NHS Trust
University of Liverpool Trials Biobank

 

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

13201

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Cara took part in a clinical trial

A picture of Cara

"I am glad that taking part in a trial might help others on their own cancer journey.”

Last reviewed:

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