A study to learn more about treatment for advanced melanoma (IMAGE)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Skin cancer




Phase 4

This study is collecting information about people having treatment for melanoma that cannot be removed with surgery or has spread to another part of the body. This is also known as advanced melanoma.

Doctors can treat advanced melanoma with a type of biological therapy called ipilimumab.

Researchers want to learn more about how ipilimumab affects people, the side effects they have, and how well any side effects can be controlled.

They also want to find out more about other treatments people are having for advanced melanoma and the impact that different treatments have on peoples’ quality of life.

Joining this study will not change your treatment, and you may not get any direct benefit from taking part. The researchers hope that the information they collect will help to improve treatment for people with melanoma in the future.

Who can enter

You may be able to enter this trial if you

  • Have melanoma that cannot be removed with surgery, or has spread to another part of your body
  • Are at least 18 years old

To take part, you must have started treatment for advanced melanoma in the last 3 weeks, or if you haven’t started treatment yet, it must have been decided which treatment you are going to have before you agree to take part in the trial. And you must start this treatment within the next 4 weeks.

You cannot enter this trial if you are

  • Taking part (or are going to take part) in another clinical trial looking at an experimental cancer drug to treat your advanced melanoma
  • Currently having treatment for any type of cancer other than melanoma

Trial design

This phase 4 trial will recruit about 1,800 people around the world. Everybody taking part will be having treatment for advanced melanoma. Some people will be having ipilimumab.

If you join the study, your doctor will fill out a questionnaire giving information about you, such as your age and gender as well as details about the stage of your melanoma and your treatment.

The researchers would like to monitor how you are for 3 years. During the study, they will ask you to fill out questionnaires every 3 months asking how your treatment has affected you. You can fill these in on paper or online via the study website. All the information you provide is confidential Open a glossary item.

Hospital visits

Taking part in this study does not change the tests or treatment you have and does not involve any extra hospital visits.

Side effects

You may find it upsetting to complete the questionnaires. If this happens, the study team can offer support and counselling that may help you.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Toby Talbot

Supported by

Bristol-Myers Squibb
NIHR Clinical Research Network: Cancer

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 9587

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

Last reviewed:

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