A study looking at the genetics of chronic lymphocytic leukaemia

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers
Chronic leukaemia
Chronic lymphocytic leukaemia (CLL)





This study is trying to find out more about the genes that might cause chronic lymphocytic leukaemia. This study is only open to people in the North Trent Cancer Network. This covers South Yorkshire, North Derbyshire and Bassetlaw.

In this study the researchers will look at the family history and genes of a large number of people with chronic lymphocytic leukaemia (CLL) and compare them with people who do not have CLL.

The aim of this study is to identify genes that may increase the risk of CLL.

Please note you won’t get any direct benefit from taking part in this study, nor will it affect any treatment you have. The findings may help people with CLL in the future.

Who can enter

You can enter this trial if you live in the North Trent area and have CLL.

You cannot enter this trial if

Trial design

This study will recruit about 720 people in total from the North Trent Cancer Network. About 350 will have CLL and 350 will not.

For people with CLL your doctor at the hospital will invite you to take part in this study. Or you will receive a letter, with a reply slip and pre paid envelope, inviting you to take part.

For people who do not have CLL, your GP will send you a letter inviting you to take part in this study. The letter will explain the study and have a reply slip and pre paid envelope with it.

The researchers will interview everyone taking part in this study. They will ask questions about you, your family and the history of cancer in your family.

They will take a sample of your blood and saliva. They will use these samples to look at genes in the cells.

They will arrange to do this at a place most convenient to you. It can be at the hospital, your GP surgery or your own home.

They will also ask permission to look at your medical records.

The researchers will ask your permission to store all this information in a computer. It will be stored using a coded number, with no personal details, such as your name and address. So it will not be possible to identify you. The researchers will also ask your permission to share this information with their research partners at the University of Utah.

Hospital visits

There are no extra hospital visits if you take part in this study.

Side effects

You may have a bit of discomfort when you have your blood sample taken.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Prof Angela Cox

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
National Cancer Institute (NCI)
University of Sheffield
University of Utah

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 7094

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Charlie took part in a trial to try new treatments

A picture of Charlie

“I think it’s really important that people keep signing up to these type of trials to push research forward.”

Last reviewed:

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