A study looking in detail at prostate cancer genes (PROGENY)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Prostate cancer





This study is looking in detail at the genes of prostate cancer cells.

More about this trial

We don’t fully understand

  • How prostate cancer develops
  • Why some cancers spread and others don’t
  • Why some prostate cancers respond to treatment and others don’t

We may find the answer to these questions in the genes of prostate cancer cells.

The study team want to take a number of samples of tissue (biopsies Open a glossary item) of your prostate cancer. They will compare tissue samples to look for differences in the genes.

The aim is to find out if the differences in the genes can help answer these questions.

Please note it is very unlikely that you would get any direct benefit from taking part in this study, nor will it affect any treatment you have. The findings may help men with prostate cancer in the future.

Who can enter

You may be able to enter this trial if

You cannot enter this trial if you

  • Are unable to have a biopsy done
  • Are unable to have a MRI scan or CT scan
  • Are taking medication that damps down your immune system or your immune system isn’t working well enough
  • Have a condition that makes you bleed easily

Trial design

This study will recruit about 200 men who are going to have a template biopsy of their prostate.

The study team will ask for up to 6 extra pieces of tissue to be taken when you have your biopsy. They will also ask for some blood samples.

They will use these samples to look at the genetic material in the prostate cancer cells. They will compare it with the normal genetic material in your blood.

Hospital visits

There are no extra visits to the hospital if you agree to take part in this study.

Side effects

The most common side effects of having a template biopsy of the prostate gland are

  • Pain or discomfort
  • Burning sensation when passing urine
  • Blood in your urine
  • Blood in your semen
  • Difficulty getting a full erection

These will get better. Your doctor can tell you how long it may take.

We have information about template biopsy on our prostate cancer tests page.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Mr Hashim Ahmed

Supported by

NIHR Clinical Research Network: Cancer
Prostate Cancer Foundation
University College London (UCL)

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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