A study looking at the treatment of intracranial germ cell tumours in children and young people (SIOP CNS GCT II)

Cancer type:

Brain (and spinal cord) tumours
Children's cancers

Status:

Open

Phase:

Other

This study is looking at the treatment of rare brain tumours called germ cell tumours.The study is supported by Cancer Research UK.

The study is for children and young people. We use the term ‘you’ in this summary, but of course if you are a parent, we are referring to your child.

Germ cell tumours that start in the brain or spinal cord (the central nervous system) are very rare. Doctors use surgery, chemotherapy and radiotherapy to treat these tumours. But there are different types of germ cell tumours and doctors want to learn more about the best ways of treating the different types. Everybody taking part in this study will have the treatment that their specialist thinks is best for them.

The aim of this study is to collect information about the treatment of germ cell tumours that start in the brain. There may not be any direct benefit from taking part in this study. But the results may help to improve treatment for children and young people with germ cell tumours in the future.

Who can enter

You may be able to enter this trial if you have been diagnosed with a germ cell tumour that started in your central nervous system.

You cannot enter this trial if you

  • Were diagnosed before the study opened in the country where you live
  • Have any other medical condition or problem that the study team think could affect your treatment
  • Are taking part in another trial of treatment for germ cell tumours
  • Are pregnant or breastfeeding

Trial design

This international study will recruit about 400 people. Everybody taking part will have the treatment that their specialist thinks is best for them. The study team will collect information for at least 5 years about the tests, scans and treatment that people have.

If you have a tissue sample (biopsy) taken of your tumour, the study team will get a sample of this to check the type of tumour you have. If any tissue is left after you have surgery or a biopsy to diagnose your tumour, the study team will ask your permission to keep a sample of this for future research. If you don’t want to give these samples for research, you don’t have to. You can still take part in the study.

The study team will also ask you to fill out some questionnaires at different points during your treatment. The questionnaires will ask about any treatment side effects and how you’ve been feeling. This is called a quality of life study.

Hospital visits

The number of hospital visits you have will depend on your particular treatment plan.

Side effects

Your specialist will talk to you about the possible side effects of any treatment you have. As taking part in this study will not change your treatment, there will not be any extra side effects.

Location

Aberdeen
Belfast
Birmingham
Bristol
Cambridge
Cardiff
Edinburgh
Glasgow
Leeds
Liverpool
London
Manchester
Newcastle upon Tyne
Nottingham
Oxford
Sheffield
Southampton
Sutton

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr James Nicholson

Supported by

Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
International Society of Paediatric Oncology (SIOP)
NIHR Clinical Research Network: Cancer

Other information

This is Cancer Research UK trial number CRUK/10/038.

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

6178

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Wendy took part in a new trial studying the possible side effect of hearing loss

A picture of Wendy

"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

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