"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study to find out more about cabazitaxel for prostate cancer that has spread and is no longer responding to hormone therapy (GenCab)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is trying to find out more about how cabazitaxel (Jevtana) works for men whose prostate cancer has spread and is no longer responding to hormone therapy.
Doctors can treat prostate cancer that has spread with hormone therapy. This may keep it under control for a long period of time. If the hormone therapy stops controlling the cancer, doctors may use a chemotherapy drug called docetaxel. If the cancer starts to grow again after docetaxel they may use cabazitaxel.
We know from research that cabazitaxel can help men who have already been treated with hormone therapy and docetaxel.
In this study, researchers will take blood samples and samples of cancer tissue from men who are having cabazitaxel. They will look at the tissue samples to look for clues as to whether or not cabazitaxel will continue to work. They will look for prostate cancer cells in the blood samples to see if they can find the same information.
Who can enter
You may be able to enter this study if you are having treatment at the Freeman Hospital, Newcastle upon Tyne and your prostate cancer
- Has spread to another part of your body
- Is no longer responding to hormone treatment
- Has continued to grow despite having docetaxel
This study will recruit 30 men.
Everybody taking part has cabazitaxel. You have it as a drip into a vein once every 3 weeks. You have up to 10 injections.
The study team will take some extra blood samples when you have other routine blood tests.
They will also take a small piece of tissue from your prostate gland (a prostate biopsy) before starting treatment and 4 weeks after finishing treatment.
They may also ask you to have a
The team will ask you to fill out a questionnaire before you start cabazitaxel, during your treatment and after you finish cabazitaxel. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.
You see the study doctors before taking part in this study to have some tests. These tests include
During treatment you go to hospital every 3 weeks for cabazitaxel injections. At each visit, you see the doctor for a physical examination and blood tests.
After treatment you see the doctor for the same tests you had at the start of the study, apart from the bone scan.
The side effects of a prostate biopsy include
- Discomfort during the biopsy – you will have painkillers for this
- Infection - you have antibiotics to help prevent this
- A small amount of bleeding into your urine, semen or stool (faeces) for a short time after the test
Your doctor will talk to you about possible side effects of cabazitaxel.
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
The Newcastle upon Tyne Hospitals NHS Foundation Trust