A study to find out more about cabazitaxel for prostate cancer that has spread and is no longer responding to hormone therapy (GenCab)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Prostate cancer





This study is trying to find out more about how cabazitaxel (Jevtana) works for men whose prostate cancer has spread and is no longer responding to hormone therapy.

Doctors can treat prostate cancer that has spread with hormone therapy. This may keep it under control for a long period of time. If the hormone therapy stops controlling the cancer, doctors may use a chemotherapy drug called docetaxel. If the cancer starts to grow again after docetaxel they may use cabazitaxel.

We know from research that cabazitaxel can help men who have already been treated with hormone therapy and docetaxel.

In this study, researchers will take blood samples and samples of cancer tissue from men who are having cabazitaxel. They will look at the tissue samples to look for clues as to whether or not cabazitaxel will continue to work. They will look for prostate cancer cells in the blood samples to see if they can find the same information.

Who can enter

You may be able to enter this study if you are having treatment at the Freeman Hospital, Newcastle upon Tyne and your prostate cancer

  • Has spread to another part of your body
  • Is no longer responding to hormone treatment
  • Has continued to grow despite having docetaxel

Trial design

This study will recruit 30 men.

Everybody taking part has cabazitaxel. You have it as a drip into a vein once every 3 weeks. You have up to 10 injections.

The study team will take some extra blood samples when you have other routine blood tests.

They will also take a small piece of tissue from your prostate gland (a prostate biopsy) before starting treatment and 4 weeks after finishing treatment.

They may also ask you to have a biopsy Open a glossary item taken from cancer that has spread to another part of your body. They will use a special needle to take the biopsy. You have an injection to numb the area (local anaesthetic Open a glossary item) to the area before the biopsy is taken.

The team will ask you to fill out a questionnaire before you start cabazitaxel, during your treatment and after you finish cabazitaxel. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.

Hospital visits

You see the study doctors before taking part in this study to have some tests. These tests include

During treatment you go to hospital every 3 weeks for cabazitaxel injections. At each visit, you see the doctor for a physical examination and blood tests.

After treatment you see the doctor for the same tests you had at the start of the study, apart from the bone scan.

Side effects

The side effects of a prostate biopsy include

  • Discomfort during the biopsy – you will have painkillers for this
  • Infection - you have antibiotics to help prevent this
  • A small amount of bleeding into your urine, semen or stool (faeces) for a short time after the test

Your doctor will talk to you about possible side effects of cabazitaxel.

We have more information about having a prostate biopsy on our prostate cancer tests page and information on cabazitaxel in our cancer drugs section.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Rakesh Heer
Ian Pedley

Supported by

Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
The Newcastle upon Tyne Hospitals NHS Foundation Trust

Questions about cancer? Contact our information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 10156

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Keith took part in a trial looking into hormone therapy

A picture of Keith

"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”

Last reviewed:

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