Chronic myeloid leukaemia (CML) incidence statistics

Cases

New cases of chronic myeloid leukaemia, 2015, UK

 

Proportion of all cases

Percentage chronic myeloid leukaemia is of total cancer cases, 2015, UK

 

Age

Peak rate of chronic myeloid leukaemia cases, 2013-2015, UK

 

 

Trend over time

Change in chronic myeloid leukaemia cancer incidence rates since the early 1990s, UK

Chronic myeloid leukaemia is not among the 20 most common cancers in the UK, accounting for less than 1% of all new cancer cases (2015).[1-4]

In males in the UK, chronic myeloid leukaemia is not among the 20 most common cancers (less than 1% of all new male cancer cases). In females in the UK it is not among the 20 most common cancers (less than 1% of all new female cancer cases).

55% of chronic myeloid leukaemia cases in the UK are in males, and 45% are in females.

Chronic myeloid leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item ) are similar to the UK average in all the UK constituent countries.

Chronic Myeloid Leukaemia (C92.1), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2015

  England Scotland Wales Northern Ireland UK
Male Cases 342 26 31 9 408
Crude Rate 1.3 1.0 2.0 1.0 1.3
AS Rate 1.4 1.0 2.1 1.0 1.4
AS Rate - 95% LCI 1.3 0.6 1.4 0.4 1.3
AS Rate - 95% UCI 1.6 1.4 2.9 1.7 1.5
Female Cases 282 26 20 6 334
Crude Rate 1.0 0.9 1.3 0.6 1.0
AS Rate 1.0 0.9 1.2 0.7 1.0
AS Rate - 95% LCI 0.9 0.6 0.6 0.1 0.9
AS Rate - 95% UCI 1.1 1.3 1.7 1.3 1.1
Persons Cases 624 52 51 15 742
Crude Rate 1.1 1.0 1.6 0.8 1.1
AS Rate 1.2 1.0 1.6 0.9 1.2
AS Rate - 95% LCI 1.1 0.7 1.2 0.4 1.1
AS Rate - 95% UCI 1.3 1.3 2.1 1.4 1.3

95% LCL and 95% UCL are the 95% lower and upper confidence limits  Open a glossary item around the AS Rate Open a glossary item
 

For chronic myeloid leukaemia, there are few established risk factors therefore differences between countries largely reflect differences in diagnosis and data recording.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2015, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia incidence is related to age, with the highest incidence rates being in older people. In the UK in 2013-2015, on average each year around a quarter (26%) of new cases were in people aged 75 and over.[1-4

Age-specific incidence rates rise gradually from birth and more steeply from around age 65-69. The highest rates are in the 85 to 89 age group for males and females.

Incidence rates are significantly higher in males than females in a few (mainly older) age groups. The gap is widest at age 70 to 74, when the age-specific incidence rate is 1.7 times higher in males than females.

Chronic Myeloid Leukaemia (C92.1), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2013-2015

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item
 

For chronic myeloid leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2013-2015, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia European age-standardised (AS) Open a glossary item incidence rates for males and females combined decreased by 31% in the UK between 1993-1995 and 2013-2015.[1-4] The decrease was larger in males than in females.

For males, chronic myeloid leukaemia AS incidence rates in the UK decreased by 39% between 1993-1995 and 2013-2015. For females, chronic myeloid leukaemia AS incidence rates in the UK decreased by 27% between 1993-1995 and 2013-2015.

Over the last decade in the UK (between 2003-2005 and 2013-2015), chronic myeloid leukaemia AS incidence rates for males and females combined remained stable. In males AS incidence rates remained stable, and in females rates remained stable.

Chronic Myeloid Leukaemia (C92.1), European Age-Standardised Incidence Rates, UK, 1993-2015

Chronic myeloid leukaemia incidence rates have varied between age groups in males and females combined in the UK since the early 1990s.[1-4] Rates in 0-24s have remained stable, in 25-49s have increased by 25%, in 50-59s have remained stable, in 60-69s have decreased by 19%, in 70-79s have decreased by 46%, and in 80+s have decreased by 61%.

Chronic Myeloid Leukaemia (C92.1), European Age-Standardised Incidence Rates, By Age, UK, 1993-2015

For chronic myeloid leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording, plus changes in the definition of Chronic myelodi leukaemia.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2015, ICD-10 C92.1.

Last reviewed:

There is no evidence for an association between chronic myeloid leukaemia (CML) incidence and deprivation for either males or females in England.[1] England-wide data for 2006-2010 show European age-standardised Open a glossary item  incidence rates are similar for both males and females living in the most deprived areas compared with the least deprived.[1]

Chronic Myeloid Leukaemia (C92.1), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

The estimated deprivation gradient in CML incidence between people living in the most and least deprived areas in England has not changed in the period 1996-2010.[1]

Reference

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for: England, 2006-2010, ICD-10 C92.1

Deprivation gradient statistics were calculated using incidence data for 2006-2010. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

An estimated 6,000 people who had been diagnosed with chronic myeloid leukaemia (CML) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991-2010) and Northern Ireland (1993-2010), ICD-10 C92.1

Last reviewed:

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