Chronic myeloid leukaemia (CML) incidence statistics

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Cases

New cases of chronic myeloid leukaemia, 2015-2017, UK.

 

Proportion of all cases

Percentage chronic myeloid leukaemia is of total cancer cases, 2015-2017, UK

 

Age

Peak rate of chronic myeloid leukaemia cases, 2015-2017, UK

 

Trend over time

Change in chronic myeloid leukaemia incidence rates since the early 1990s, UK

 

Chronic myeloid leukaemia accounted for less than 1% of all new cancer cases in the UK in 2017.[1-4]

In females in the UK, chronic myeloid leukaemia accounted for less than 1% of all new female cancer cases. In males in the UK, it accounted for less than 1% of all new male cancer cases).

46% of chronic myeloid leukaemia cases in the UK are in females, and 54% are in males.

Chronic myeloid leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item) for persons are similar to the UK average in all the UK constituent countries.

Chronic Myeloid Leukaemia (C92.1), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2017

  England Scotland Wales Northern Ireland UK
Female Cases 333 30 17 4 384
Crude Rate 1.2 1.1 1.1 0.4 1.1
AS Rate 1.2 1.1 1.0 0.5 1.2
AS Rate - 95% LCL 1.1 0.7 0.6 0.0 1.0
AS Rate - 95% UCL 1.3 1.4 1.5 0.9 1.3
Male Cases 387 30 17 11 445
Crude Rate 1.4 1.1 1.1 1.2 1.4
AS Rate 1.6 1.2 1.1 1.4 1.5
AS Rate - 95% LCL 1.4 0.8 0.6 0.6 1.4
AS Rate - 95% UCL 1.7 1.7 1.7 2.3 1.6
Persons Cases 720 60 34 15 829
Crude Rate 1.3 1.1 1.1 0.8 1.3
AS Rate 1.4 1.1 1.1 0.9 1.3
AS Rate - 95% LCL 1.3 0.8 0.7 0.5 1.2
AS Rate - 95% UCL 1.5 1.4 1.5 1.4 1.4

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, November 2019. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2019. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, December 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2017, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia incidence is related to age, with the highest incidence rates being in older people. In the UK in 2015-2017, on average each year almost a quarter of new cases (23%) were in people aged 75 and over.[1-4]

Age-specific incidence rates rise gradually from birth and more steeply from around age 65-69. The highest rates are in the 85 to 89 age group for females and males.

Incidence rates are similar between females and males in most age groups.

Chronic myeloid leukaemia (C92.1), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2015-2017

For chronic myeloid leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, November 2019. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2019. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, December 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2015-2017, C92.1.

Last reviewed:

Chronic myeloid leukaemia European age-standardised (AS) Open a glossary item incidence rates for females and males combined decreased by 30% in the UK between 1993-1995 and 2015-2017.[1-4] The decrease was larger in males than in females.

For females, chronic myeloid leukaemia AS incidence rates in the UK decreased by 24% between 1993-1995 and 2015-2017. For males, chronic myeloid leukaemia AS incidence rates in the UK decreased by 40% between 1993-1995 and 2015-2017.

Over the last decade in the UK (between 2005-2007 and 2015-2017), chronic myeloid leukaemia AS incidence rates for females and males combined remained stable. In females AS incidence rates remained stable, and in males rates remained stable.

Chronic Myeloid Leukaemia (ICD-10 C92.1), European Age-Standardised Incidence Rates, UK, 1993-2017

Chronic myeloid leukaemia incidence rates have remained stable overall in some broad age groups in females and males combined in the UK since the early 1990s, but have increased or decreased in others.[1-4] Rates in 0-24s have remained stable, in 25-49s have increased by 33%, in 50-59s have remained stable, in 60-69s have remained stable, in 70-79s have decreased by 48%, and in 80+s have decreased by 66%.

Chronic Myeloid Leukaemia (ICD-10 C92.1), European Age-Standardised Incidence Rates, By Age, UK, 1993-2017

For chronic myeloid leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording, plus changes in the definition of CML.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, November 2019. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2019. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, December 2019. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2017, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item) in England in females are similar in the most deprived quintile compared with the least, and in males are similar in the most deprived quintile compared with the least (2013-2017).[1]

References

  1. Calculated by the Cancer Intelligence Team at Cancer Research UK, April 2020. Based on method reported in National Cancer Intelligence Network Cancer by Deprivation in England Incidence, 1996-2010 Mortality, 1997-2011 . Using cancer incidence data 2013-2017 (Public Health England) and population data 2013-2017 (Office for National Statistics) by Indices of Multiple Deprivation 2015 income domain quintile, cancer type, sex, and five-year age band.

About this data

Data is for England, 2013-2017, ICD-10 C92.1.

Last reviewed:

An estimated 6,000 people who had been diagnosed with chronic myeloid leukaemia (CML) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991-2010) and Northern Ireland (1993-2010), ICD-10 C92.1

Last reviewed:

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