Chronic myeloid leukaemia (CML) incidence statistics

Cases

New cases of chronic myeloid leukaemia each year, 2016-2018 average, UK.

 

Proportion of all cases

Percentage chronic myeloid leukaemia is of total cancer cases, 2016-2018, UK

 

Age

Peak rate of chronic myeloid leukaemia cases, 2016-2018, UK

 

Trend over time

Change in chronic myeloid leukaemia incidence rates since the early 1990s, UK

 

Chronic myeloid leukaemia accounted for less than 1% of all new cancer cases in the UK in 2016-2018.[1-4]

In females in the UK, chronic myeloid leukaemia accounted for less than 1% of all new female cancer cases. In males in the UK, it accounted for less than 1% of all new male cancer cases).

45% of chronic myeloid leukaemia cases in the UK are in females, and 55% are in males.

Chronic myeloid leukaemia incidence rates (European age-standardised (AS) rate Open a glossary item) for persons are significantly lower than the UK average in Wales and similar to the UK average in all other UK constituent countries.

For chronic myeloid leukaemia, there are few established risk factors therefore differences between countries largely reflect differences in diagnosis and data recording.

Chronic Myeloid Leukaemia (C92.1), Average Number of New Cases Per Year, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2016-2018

  England Scotland Wales Northern Ireland UK
Female Cases 314 32 17 8 370
Crude Rate 1.1 1.1 1.1 0.8 1.1
AS Rate 1.1 1.1 1.0 0.9 1.1
AS Rate - 95% LCL 1.1 0.9 0.7 0.5 1.1
AS Rate - 95% UCL 1.2 1.3 1.3 1.2 1.2
Male Cases 395 36 16 13 459
Crude Rate 1.4 1.4 1.0 1.4 1.4
AS Rate 1.6 1.5 1.1 1.6 1.5
AS Rate - 95% LCL 1.5 1.2 0.8 1.1 1.5
AS Rate - 95% UCL 1.7 1.7 1.4 2.1 1.6
Persons Cases 709 68 33 20 829
Crude Rate 1.3 1.2 1.0 1.1 1.3
AS Rate 1.3 1.3 1.0 1.2 1.3
AS Rate - 95% LCL 1.3 1.1 0.8 0.9 1.3
AS Rate - 95% UCL 1.4 1.4 1.2 1.5 1.4

95% LCL and 95% UCL are the 95% lower and upper confidence limits around the AS Rate Open a glossary item

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, July 2021. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2020. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were published by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales https://phw.nhs.wales/services-and-teams/welsh-cancer-intelligence-and-surveillance-unit-wcisu/cancer-incidence-in-wales-2002-2018/, March 2021.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2020. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2016-2018, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia incidence is related to age, with the highest incidence rates being in older people. In the UK in 2016-2018, on average each year almost a quarter of new cases (23%) were in people aged 75 and over.[1-4]

Age-specific incidence rates rise gradually from birth and more steeply from around age 65-69. The highest rates are in in the 85 to 89 age group for females and the 90+ age group for males.

Incidence rates are similar between females and males in most age groups.

Chronic myeloid leukaemia (C92.1), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2016-2018

For chronic myeloid leukaemia, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, July 2021. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2020. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were published by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales https://phw.nhs.wales/services-and-teams/welsh-cancer-intelligence-and-surveillance-unit-wcisu/cancer-incidence-in-wales-2002-2018/, March 2021.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2020. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2016-2018, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia European age-standardised (AS) Open a glossary item incidence rates for females and males combined decreased by 28% in the UK between 1993-1995 and 2016-2018.[1-4] The decrease was larger in males than in females.

For females, chronic myeloid leukaemia AS incidence rates in the UK decreased by 21% between 1993-1995 and 2016-2018. For males, chronic myeloid leukaemia AS incidence rates in the UK decreased by 37% between 1993-1995 and 2016-2018.

Over the last decade in the UK (between 2006-2008 and 2016-2018), chronic myeloid leukaemia AS incidence rates for females and males combined remained stable. In females AS incidence rates increased by 17%, and in males rates remained stable.

Chronic Myeloid Leukaemia (C92.1), European Age-Standardised Incidence Rates, UK, 1993 to 2018

Chronic myeloid leukaemia incidence rates have varied between age groups in females and males combined in the UK since the early 1990s.[1-4] Rates in 0-24s have remained stable, in 25-49s have increased by 41%, in 50-59s have remained stable, in 60-69s have decreased by 19%, in 70-79s have decreased by 46% and in 80+s have decreased by 65%.

Chronic Myeloid Leukaemia (C92.1), European Age-Standardised Incidence Rates per 100,000 Persons Population, By Age, UK, 1993-2018

For chronic myeloid leukaemia there are few established risk factors, therefore increasing incidence in the 1980s and 1990s may largely reflect improvements in diagnosis and data recording, plus changes in the definition of CML.

References

  1. Data were provided by the National Cancer Registration and Analysis Service (part of Public Health England), on request through the Office for Data Release, July 2021. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases
  2. Data were provided by ISD Scotland on request, April 2020. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were published by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales https://phw.nhs.wales/services-and-teams/welsh-cancer-intelligence-and-surveillance-unit-wcisu/cancer-incidence-in-wales-2002-2018/, March 2021.
  4. Data were provided by the Northern Ireland Cancer Registry on request, May 2020. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2018, ICD-10 C92.1.

Last reviewed:

Chronic myeloid leukaemia incidence rates (European age-standardised (AS) rates Open a glossary item) in England in females are similar in the most deprived quintile compared with the least, and in males are similar in the most deprived quintile compared with the least (2013-2017).[1]

References

  1. Calculated by the Cancer Intelligence Team at Cancer Research UK, April 2020. Based on method reported in National Cancer Intelligence Network Cancer by Deprivation in England Incidence, 1996-2010 Mortality, 1997-2011 . Using cancer incidence data 2013-2017 (Public Health England) and population data 2013-2017 (Office for National Statistics) by Indices of Multiple Deprivation 2015 income domain quintile, cancer type, sex, and five-year age band.

About this data

Data is for England, 2013-2017, ICD-10 C92.1.

Last reviewed:

An estimated 6,000 people who had been diagnosed with chronic myeloid leukaemia (CML) between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991-2010) and Northern Ireland (1993-2010), ICD-10 C92.1

Last reviewed:

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