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A trial using circulating tumour DNA to help decide when to change treatment for advanced melanoma (CAcTUS)

Overview

Cancer types:

Melanoma, Secondary cancers

Status:

Results

Phase:

Pilot

Details

This trial looked at whether measuring can help doctors decide when to change from targeted treatment to immunotherapy.

It was for people with melanoma which:

  • couldn’t be removed with surgery, or had spread elsewhere in the body

  • had a specific change in the BRAF called BRAF V600E

People could join this study between 2019 and 2022. The team analysed the results in 2023.

Recruitment start: 2 May 2019

Recruitment end: 30 September 2022

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Paul Lorigan

Supported by

Bristol-Myers Squibb

The Christie NHS Foundation Trust

University of Manchester

Last reviewed: 04 Feb 2026

CRUK internal database number: 17883

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