Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial of TPF chemotherapy before surgery and radiotherapy for locally advanced head and neck cancer (TITAN)
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This trial looked at chemotherapy before surgery and radiotherapy for people who have
If you have head and neck cancer that has grown into surrounding body tissues (
But sometimes the cancer will come back and doctors are looking for ways to improve treatment. In this trial, they looked at chemotherapy before surgery. This is called induction chemotherapy. It is a combination of 3 drugs called docetaxel, cisplatin and fluorouracil. This combination of drugs is also known as TPF. We have information about TPF.
We know from research that TPF can shrink head and neck cancers. But we don’t know if having this type of chemotherapy before surgery makes a difference to the long term outcome.
The aim of the trial was to see if having induction chemotherapy before standard treatment helped people with locally advanced squamous cell cancer of the head and neck.
Summary of results
This was only a feasibility study, there won’t be any results.
How to join a clinical trial
Mr Richard Shaw
Aintree University Hospitals NHS Foundation Trust
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
University of Liverpool
This is Cancer Research UK trial number CRUK/10/013.