A trial of nivolumab and decitabine for a brain tumour called glioblastoma (COMBAT-GB)

Overview

Cancer types:

Brain (and spinal cord) tumours

Status:

Open

Phase:

Phase 1

Details

This trial is looking at nivolumab and decitabine for a type of primary brain tumour called a glioblastoma. A primary brain tumour is one that started in the brain.

It is open to people who have a newly diagnosed glioblastoma.

Recruitment start: 2 February 2026

Recruitment end: 30 June 2028

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Puneet Plaha

Supported by

Cancer Research UK

University of Oxford

Brainstorm

Oxford Hospitals Charity

Other information

This is Cancer Research UK trial number CRUK/22/008.

Last reviewed: 27 Jul 2026

CRUK internal database number: 19937

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