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A trial looking at zilovertamab vedotin and R-CHP for diffuse large B cell lymphoma (waveLINE-011)

Overview

Cancer types:

Blood cancers, High grade lymphoma, Lymphoma, Non-Hodgkin lymphoma (NHL)

Status:

Open

Phase:

Phase 2

Details

This trial is looking at adding zilovertamab vedotin to a combination of cancer drugs called R-CHP. It is comparing this with another drug called polatuzumab vedotin alongside R-CHP.

It is for people who:

  • have a specific type of diffuse large B cell lymphoma called germinal centre B cell

  • haven’t had treatment yet

You pronounce zilovertamab vedotin as zi-lov-er-ta-mab veh-doh-tin.

You pronounce polatuzumab vedotin as poh-lah-too-zoo-mab veh-doh-tin.

Recruitment start: 30 September 2025

Recruitment end: 12 August 2027

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Sanne Lugthart

Supported by

Merck Sharp & Dohme LLC

Last reviewed: 14 Jan 2026

CRUK internal database number: 20127

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