Blood cancers, High grade lymphoma, Lymphoma, Non-Hodgkin lymphoma (NHL)
Open
Phase 2
This trial is looking at adding zilovertamab vedotin to a combination of cancer drugs called R-CHP. It is comparing this with another drug called polatuzumab vedotin alongside R-CHP.
It is for people who:
have a specific type of diffuse large B cell lymphoma called germinal centre B cell
haven’t had treatment yet
You pronounce zilovertamab vedotin as zi-lov-er-ta-mab veh-doh-tin.
You pronounce polatuzumab vedotin as poh-lah-too-zoo-mab veh-doh-tin.
Recruitment start: 30 September 2025
Recruitment end: 12 August 2027
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Sanne Lugthart
Merck Sharp & Dohme LLC
Last reviewed: 14 Jan 2026
CRUK internal database number: 20127