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A trial looking at zilovertamab vedotin by itself or with nemtabrutinib for B cell lymphoma and B cell leukaemia (waveLINE-006)

Overview

Cancer types:

Blood cancers, Cell type, Chronic leukaemia, Chronic lymphocytic leukaemia (CLL), Leukaemia, Lymphoma

Status:

Open

Phase:

Phase 2

Details

This trial is looking at zilovertamab vedotin by itself or in combination with nemtabrutinib for people with B cell lymphomas and B cell leukaemia.

B cell lymphoma and B cell leukaemia are also called B cells cancers.

It is open to people with one of the following B cell cancers that has come back or got worse during treatment:

  • mantle cell lymphoma

  • follicular lymphoma

  • Richter transformation . This is also called Richter’s syndrome.

You pronounce zilovertamab vedotin as zi-lov-er-ta-mab ve-dot-in.

You pronounce nemtabrutinib as nem-tab-rut-i-nib.

Recruitment start: 31 July 2023

Recruitment end: 22 April 2027

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Satyen Gohil

Supported by

Merck Sharp & Dohme

Last reviewed: 15 May 2025

CRUK internal database number: 19601

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