Breast cancer, Secondary cancers
Open
Phase 1/2
This trial is looking at trastuzumab pamirtecan and pumitamig for breast cancer that has spread and cannot be removed by surgery.
It is for people with breast cancer that has:
spread into the surrounding tissue (locally advanced) or
spread to another part of the body (advanced cancer)
You pronounce trastuzumab pamirtecan as tras-too-zoo-mab pam-ir-tee-can and pumitamig as puh-mih-tah-mig.
Trastuzumab pamirtecan is also called BNT323. Pumitamig is also called BNT327.
Recruitment start: 28 August 2025
Recruitment end: 31 December 2027
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Richard Baird
BioNTech SE
IQVIA
Last reviewed: 27 Mar 2026
CRUK internal database number: 20135