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A trial looking at trastuzumab pamirtecan and pumitamig for breast cancer that has spread

Overview

Cancer types:

Breast cancer, Secondary cancers

Status:

Open

Phase:

Phase 1/2

Details

This trial is looking at trastuzumab pamirtecan and pumitamig for breast cancer that has spread and cannot be removed by surgery.

It is for people with breast cancer that has:

  • spread into the surrounding tissue (locally advanced) or

  • spread to another part of the body (advanced cancer)

You pronounce trastuzumab pamirtecan as tras-too-zoo-mab pam-ir-tee-can and pumitamig as puh-mih-tah-mig.

Trastuzumab pamirtecan is also called BNT323. Pumitamig is also called BNT327.

Recruitment start: 28 August 2025

Recruitment end: 31 December 2027

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Richard Baird

Supported by

BioNTech SE

IQVIA

Last reviewed: 27 Mar 2026

CRUK internal database number: 20135

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