Lung cancer, Non small cell lung cancer (NSCLC), Secondary cancers
Open
Phase 3
This trial is looking at adding calderasib to pembrolizumab to improve treatment for non small cell lung cancer.
It is for people who:
have been newly diagnosed with non small cell lung cancer
have a gene change () called KRAS G12C in their lung cancer cells
have a large number of cancer cells that have a protein called PD-L1
You pronounce calderasib as kal-dair-ah-sib.
Recruitment start: 21 November 2025
Recruitment end: 19 February 2027
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Azhar Rizvi
Merck Sharp & Dohme LLC
Last reviewed: 20 Aug 2026
CRUK internal database number: 20163