Brain (and spinal cord) tumours
Open
Phase 1/2
This trial is looking at adding paxalisib to temozolomide for a type of brain tumour called glioblastoma. It is for people who have had after surgery and are planned to continue with chemotherapy. You pronounce paxalisib as pax-a-lie-sib. The 5G-PEARL trial is part of a large research programme looking at new treatments for brain tumours. The research programme is called 5G: A Next-Generation aGile Genomically Guided Glioma platform trial. It is called the 5G platform trial for short. Cancer Research UK supports this trial.
Recruitment start: 8 January 2026
Recruitment end: 19 June 2029
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Juanita Lopez
Cancer Research UK
Institute of Cancer Research (ICR)
This is Cancer Research UK trial number CRUK/23/004.
Last reviewed: 17 Mar 2026
CRUK internal database number: 20149
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