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A trial looking at divarasib, sotorasib or adagrasib for non small cell lung cancer that has spread (Krascendo 1)

Overview

Cancer types:

Lung cancer, Non small cell lung cancer (NSCLC), Secondary cancers

Status:

Closed

Phase:

Phase 3

Details

This trial is looking at a new drug called divarasib for non small cell lung cancer that has got worse after treatment. It is comparing this to a drug called sotorasib and another drug called adagrasib.

The trial is for people whose cancer:

  • has a KRAS G12C gene change () and

  • has grown into surrounding tissues or to another part of the body

You pronounce divarasib as di-va-ra-sib.

You pronounce sotorasib as so-tour-ah-sib.

You pronounce adagrasib as a-dah-gra-sib.

Recruitment start: 17 September 2024

Recruitment end: 7 May 2025

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Sanjay Popat

Supported by

Roche

Last reviewed: 15 May 2026

CRUK internal database number: 20023

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