A trial looking at calderasib and durvalumab for non small cell lung cancer (KANDLELIT-015)

Overview

Cancer types:

Lung cancer, Non small cell lung cancer (NSCLC)

Status:

Open

Phase:

Phase 3

Details

This trial is looking at adding calderasib to durvalumab for non small cell lung cancer.

It is open to people who:

  • have non small cell lung cancer that has grown or spread in the chest but has not spread to other parts of the body

  • can’t or don’t want to have surgery to treat their cancer

  • have a gene change () called KRAS G12C in their lung cancer cells

You pronounce calderasib as kal-dair-ah-sib.

Recruitment start: 10 September 2026

Recruitment end: 31 May 2031

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Pooja Bhatnagar

Supported by

Merck Sharp & Dohme Ltd

Last reviewed: 14 Oct 2026

CRUK internal database number: 20195

The Dangoor Education logo.

Dangoor Education

About Cancer generously supported by Dangoor Education since 2010. Learn more about Dangoor Education

Patient Information Forum. Trusted Information Creator.
Plain English Campaign award.

Help and support

An icon of a hand shake.

Find a Clinical Trial

Search our clinical trials database for all cancer trials and studies recruiting in the UK.

An icon of two speech bubbles, indicating a conversation.

Cancer Chat forum

Connect with other people affected by cancer and share your experiences.

An icon of a landline phone.

Nurse helpline

Questions about cancer? Call freephone 0808 800 40 40 from 9 to 5 - Monday to Friday. Alternatively, you can email us.