Bowel (colorectal) cancer, Colon cancer, Secondary cancers
Open
Phase 3
This trial is looking at calderasib, chemotherapy and cetuximab for bowel cancer that has spread. It is comparing this to having chemotherapy with or without bevacizumab.
It is open to people who:
are having their first treatment for bowel cancer that has spread
have a gene change () called KRAS G12C in their bowel cancer cells
You pronounce calderasib as kal-dair-ah-sib.
Recruitment start: 11 February 2026
Recruitment end: 30 November 2027
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Kai-Keen Shiu
Merck Sharp & Dohme LLC
Last reviewed: 10 Nov 2026
CRUK internal database number: 20189