A trial looking at calderasib for advanced solid cancer (KANDLELIT-014)

Overview

Cancer types:

All cancer types, Secondary cancers

Status:

Open

Phase:

Phase 2

Details

This trial is comparing calderasib with calderasib and cetuximab for that has spread.

It is for people whose cancer:

  • has spread into the surrounding tissues or elsewhere in the body and

  • has a gene change () called KRAS G12C

A solid cancer is any cancer apart from a blood cancer such as leukaemia, lymphoma and myeloma.

You pronounce calderasib as kal-dair-ah-sib.

Recruitment start: 25 March 2026

Recruitment end: 30 August 2030

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Colin Lindsay

Supported by

Merck Sharp & Dohme Ltd

Last reviewed: 21 Aug 2026

CRUK internal database number: 20166

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