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A trial looking at saruparib and darolutamide before surgery for prostate cancer (ASCERTAIN)

Overview

Cancer types:

Prostate cancer

Status:

Open

Phase:

Phase 1

Details

This trial is looking at having saruparib or darolutamide before surgery to remove prostate cancer. It is also looking at the combination of saruparib and darolutamide before surgery.

This trial is for men whose prostate cancer:

  • is recently diagnosed

  • hasn’t spread outside the (localised prostate cancer) and

  • has a higher risk of spreading

Recruitment start: 21 September 2023

Recruitment end: 30 September 2025

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Simon Pacey

Supported by

AstraZeneca

Last reviewed: 04 Jun 2025

CRUK internal database number: 19501

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